Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits

Inherited germline variants and somatic mutations contribute to cancer. Here, the authors present the statistical method ALFRED that tests the two-hit hypothesis of tumorigenesis and apply it to ~10,000 tumor exomes to identify rare germline variants that affect putative cancer predisposition genes,...

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Autores principales:	Solip Park, Fran Supek, Ben Lehner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b2209a275b7640d6a293216d0efe4a65
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spelling	oai:doaj.org-article:b2209a275b7640d6a293216d0efe4a652021-12-02T16:49:22ZSystematic discovery of germline cancer predisposition genes through the identification of somatic second hits10.1038/s41467-018-04900-72041-1723https://doaj.org/article/b2209a275b7640d6a293216d0efe4a652018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04900-7https://doaj.org/toc/2041-1723Inherited germline variants and somatic mutations contribute to cancer. Here, the authors present the statistical method ALFRED that tests the two-hit hypothesis of tumorigenesis and apply it to ~10,000 tumor exomes to identify rare germline variants that affect putative cancer predisposition genes, contributing substantially to cancer risk.Solip ParkFran SupekBen LehnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Solip Park Fran Supek Ben Lehner Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
description	Inherited germline variants and somatic mutations contribute to cancer. Here, the authors present the statistical method ALFRED that tests the two-hit hypothesis of tumorigenesis and apply it to ~10,000 tumor exomes to identify rare germline variants that affect putative cancer predisposition genes, contributing substantially to cancer risk.
format	article
author	Solip Park Fran Supek Ben Lehner
author_facet	Solip Park Fran Supek Ben Lehner
author_sort	Solip Park
title	Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
title_short	Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
title_full	Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
title_fullStr	Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
title_full_unstemmed	Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
title_sort	systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b2209a275b7640d6a293216d0efe4a65
work_keys_str_mv	AT solippark systematicdiscoveryofgermlinecancerpredispositiongenesthroughtheidentificationofsomaticsecondhits AT fransupek systematicdiscoveryofgermlinecancerpredispositiongenesthroughtheidentificationofsomaticsecondhits AT benlehner systematicdiscoveryofgermlinecancerpredispositiongenesthroughtheidentificationofsomaticsecondhits
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Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits

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