Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits

Inherited germline variants and somatic mutations contribute to cancer. Here, the authors present the statistical method ALFRED that tests the two-hit hypothesis of tumorigenesis and apply it to ~10,000 tumor exomes to identify rare germline variants that affect putative cancer predisposition genes,...

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Autores principales: Solip Park, Fran Supek, Ben Lehner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b2209a275b7640d6a293216d0efe4a65
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