A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, which show efficient neutralizing activities a...

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Autores principales: Tal Noy-Porat, Efi Makdasi, Ron Alcalay, Adva Mechaly, Yinon Levy, Adi Bercovich-Kinori, Ayelet Zauberman, Hadas Tamir, Yfat Yahalom-Ronen, Ma’ayan Israeli, Eyal Epstein, Hagit Achdout, Sharon Melamed, Theodor Chitlaru, Shay Weiss, Eldar Peretz, Osnat Rosen, Nir Paran, Shmuel Yitzhaki, Shmuel C. Shapira, Tomer Israely, Ohad Mazor, Ronit Rosenfeld
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b2261c0965d74199a91b395d6e6b9e4c
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spelling oai:doaj.org-article:b2261c0965d74199a91b395d6e6b9e4c2021-12-02T16:35:13ZA panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes10.1038/s41467-020-18159-42041-1723https://doaj.org/article/b2261c0965d74199a91b395d6e6b9e4c2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18159-4https://doaj.org/toc/2041-1723Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, which show efficient neutralizing activities against authentic virus in vitro.Tal Noy-PoratEfi MakdasiRon AlcalayAdva MechalyYinon LevyAdi Bercovich-KinoriAyelet ZaubermanHadas TamirYfat Yahalom-RonenMa’ayan IsraeliEyal EpsteinHagit AchdoutSharon MelamedTheodor ChitlaruShay WeissEldar PeretzOsnat RosenNir ParanShmuel YitzhakiShmuel C. ShapiraTomer IsraelyOhad MazorRonit RosenfeldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tal Noy-Porat
Efi Makdasi
Ron Alcalay
Adva Mechaly
Yinon Levy
Adi Bercovich-Kinori
Ayelet Zauberman
Hadas Tamir
Yfat Yahalom-Ronen
Ma’ayan Israeli
Eyal Epstein
Hagit Achdout
Sharon Melamed
Theodor Chitlaru
Shay Weiss
Eldar Peretz
Osnat Rosen
Nir Paran
Shmuel Yitzhaki
Shmuel C. Shapira
Tomer Israely
Ohad Mazor
Ronit Rosenfeld
A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
description Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, which show efficient neutralizing activities against authentic virus in vitro.
format article
author Tal Noy-Porat
Efi Makdasi
Ron Alcalay
Adva Mechaly
Yinon Levy
Adi Bercovich-Kinori
Ayelet Zauberman
Hadas Tamir
Yfat Yahalom-Ronen
Ma’ayan Israeli
Eyal Epstein
Hagit Achdout
Sharon Melamed
Theodor Chitlaru
Shay Weiss
Eldar Peretz
Osnat Rosen
Nir Paran
Shmuel Yitzhaki
Shmuel C. Shapira
Tomer Israely
Ohad Mazor
Ronit Rosenfeld
author_facet Tal Noy-Porat
Efi Makdasi
Ron Alcalay
Adva Mechaly
Yinon Levy
Adi Bercovich-Kinori
Ayelet Zauberman
Hadas Tamir
Yfat Yahalom-Ronen
Ma’ayan Israeli
Eyal Epstein
Hagit Achdout
Sharon Melamed
Theodor Chitlaru
Shay Weiss
Eldar Peretz
Osnat Rosen
Nir Paran
Shmuel Yitzhaki
Shmuel C. Shapira
Tomer Israely
Ohad Mazor
Ronit Rosenfeld
author_sort Tal Noy-Porat
title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
title_short A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
title_full A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
title_fullStr A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
title_full_unstemmed A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
title_sort panel of human neutralizing mabs targeting sars-cov-2 spike at multiple epitopes
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b2261c0965d74199a91b395d6e6b9e4c
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