Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Antigen-specific IL9-secreting CD4 Th9 and CD8 Tc9 cells have been previously characterized for their anti-tumour properties. Here, the authors show that ex vivo polarized Th9/Tc9 human CAR-T cells display increased anti-tumor activity in pre-clinical haematological and solid cancer models compared...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lintao Liu, Enguang Bi, Xingzhe Ma, Wei Xiong, Jianfei Qian, Lingqun Ye, Pan Su, Qiang Wang, Liuling Xiao, Maojie Yang, Yong Lu, Qing Yi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b2273200152948e6ace4d8433c52e875
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b2273200152948e6ace4d8433c52e875
record_format	dspace
spelling	oai:doaj.org-article:b2273200152948e6ace4d8433c52e8752021-12-02T15:37:14ZEnhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-910.1038/s41467-020-19672-22041-1723https://doaj.org/article/b2273200152948e6ace4d8433c52e8752020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19672-2https://doaj.org/toc/2041-1723Antigen-specific IL9-secreting CD4 Th9 and CD8 Tc9 cells have been previously characterized for their anti-tumour properties. Here, the authors show that ex vivo polarized Th9/Tc9 human CAR-T cells display increased anti-tumor activity in pre-clinical haematological and solid cancer models compared to conventional IL-2 activated CAR-T cells.Lintao LiuEnguang BiXingzhe MaWei XiongJianfei QianLingqun YePan SuQiang WangLiuling XiaoMaojie YangYong LuQing YiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lintao Liu Enguang Bi Xingzhe Ma Wei Xiong Jianfei Qian Lingqun Ye Pan Su Qiang Wang Liuling Xiao Maojie Yang Yong Lu Qing Yi Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
description	Antigen-specific IL9-secreting CD4 Th9 and CD8 Tc9 cells have been previously characterized for their anti-tumour properties. Here, the authors show that ex vivo polarized Th9/Tc9 human CAR-T cells display increased anti-tumor activity in pre-clinical haematological and solid cancer models compared to conventional IL-2 activated CAR-T cells.
format	article
author	Lintao Liu Enguang Bi Xingzhe Ma Wei Xiong Jianfei Qian Lingqun Ye Pan Su Qiang Wang Liuling Xiao Maojie Yang Yong Lu Qing Yi
author_facet	Lintao Liu Enguang Bi Xingzhe Ma Wei Xiong Jianfei Qian Lingqun Ye Pan Su Qiang Wang Liuling Xiao Maojie Yang Yong Lu Qing Yi
author_sort	Lintao Liu
title	Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
title_short	Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
title_full	Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
title_fullStr	Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
title_full_unstemmed	Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
title_sort	enhanced car-t activity against established tumors by polarizing human t cells to secrete interleukin-9
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b2273200152948e6ace4d8433c52e875
work_keys_str_mv	AT lintaoliu enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT enguangbi enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT xingzhema enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT weixiong enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT jianfeiqian enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT lingqunye enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT pansu enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT qiangwang enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT liulingxiao enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT maojieyang enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT yonglu enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9 AT qingyi enhancedcartactivityagainstestablishedtumorsbypolarizinghumantcellstosecreteinterleukin9
_version_	1718386253851787264

Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Ejemplares similares