Sequential modification of bacterial chemoreceptors is key for achieving both accurate adaptation and high gain

Bacterial chemoreceptors have multiple methylation sites, but whether the order of methylation matters is unclear. Here, the authors show that sequentially ordered methylation is critical for perfect adaptation and for attenuating the trade-off between accurate adaptation and high response gain.

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Bibliographic Details
Main Authors: Bernardo A. Mello, Anderson B. Beserra, Yuhai Tu
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/b2276006704844bcbbc28291af6c48e2
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Summary:Bacterial chemoreceptors have multiple methylation sites, but whether the order of methylation matters is unclear. Here, the authors show that sequentially ordered methylation is critical for perfect adaptation and for attenuating the trade-off between accurate adaptation and high response gain.