PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice

Non-homologous end-joining is the key pathway for repairing double-stranded DNA breaks in mammalian cells. Here the authors show that PAXX promotes the accumulation of KU at DNA breaks and is essential for end-joining in cells lacking XLF.

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Autores principales:	Xiangyu Liu, Zhengping Shao, Wenxia Jiang, Brian J. Lee, Shan Zha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b22beddb938e4935afca7966266c756f
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spelling	oai:doaj.org-article:b22beddb938e4935afca7966266c756f2021-12-02T14:40:47ZPAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice10.1038/ncomms138162041-1723https://doaj.org/article/b22beddb938e4935afca7966266c756f2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13816https://doaj.org/toc/2041-1723Non-homologous end-joining is the key pathway for repairing double-stranded DNA breaks in mammalian cells. Here the authors show that PAXX promotes the accumulation of KU at DNA breaks and is essential for end-joining in cells lacking XLF.Xiangyu LiuZhengping ShaoWenxia JiangBrian J. LeeShan ZhaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiangyu Liu Zhengping Shao Wenxia Jiang Brian J. Lee Shan Zha PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
description	Non-homologous end-joining is the key pathway for repairing double-stranded DNA breaks in mammalian cells. Here the authors show that PAXX promotes the accumulation of KU at DNA breaks and is essential for end-joining in cells lacking XLF.
format	article
author	Xiangyu Liu Zhengping Shao Wenxia Jiang Brian J. Lee Shan Zha
author_facet	Xiangyu Liu Zhengping Shao Wenxia Jiang Brian J. Lee Shan Zha
author_sort	Xiangyu Liu
title	PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
title_short	PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
title_full	PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
title_fullStr	PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
title_full_unstemmed	PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
title_sort	paxx promotes ku accumulation at dna breaks and is essential for end-joining in xlf-deficient mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b22beddb938e4935afca7966266c756f
work_keys_str_mv	AT xiangyuliu paxxpromoteskuaccumulationatdnabreaksandisessentialforendjoininginxlfdeficientmice AT zhengpingshao paxxpromoteskuaccumulationatdnabreaksandisessentialforendjoininginxlfdeficientmice AT wenxiajiang paxxpromoteskuaccumulationatdnabreaksandisessentialforendjoininginxlfdeficientmice AT brianjlee paxxpromoteskuaccumulationatdnabreaksandisessentialforendjoininginxlfdeficientmice AT shanzha paxxpromoteskuaccumulationatdnabreaksandisessentialforendjoininginxlfdeficientmice
_version_	1718390191898492928

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice

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