Prevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia

Lami Bayisa,1 Abilo Tadesse,1 Mebratu Mitiku Reta,1 Ejigu Gebeye2 1Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Institute of Public Health, University of Gondar, Gondar, EthiopiaCorrespondence: Abilo Tadesse Email abilo.tadesse@ya...

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Autores principales:	Bayisa L, Tadesse A, Reta MM, Gebeye E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	plhiv antiretroviral therapy western ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b22f9241536c4ad983f7f50bc96c0ec1
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spelling	oai:doaj.org-article:b22f9241536c4ad983f7f50bc96c0ec12021-12-02T05:44:11ZPrevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia1179-1373https://doaj.org/article/b22f9241536c4ad983f7f50bc96c0ec12020-09-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-factors-associated-with-delayed-initiation-of-antiretro-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Lami Bayisa,1 Abilo Tadesse,1 Mebratu Mitiku Reta,1 Ejigu Gebeye2 1Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Institute of Public Health, University of Gondar, Gondar, EthiopiaCorrespondence: Abilo Tadesse Email abilo.tadesse@yahoo.comBackground: Ethiopia has adopted the “Universal Test and Treat” strategy to its national policy in 2016 to put all people living with HIV/AIDS (PLHIV) on antiretroviral therapy (ART) regardless of their World Health Organization (WHO) clinical stage or CD4 cell count level. A significant percentage of PLHIV start therapy has been delayed despite the availability of ART, which results in poor treatment outcomes including HIV-related morbidity and mortality, and continued HIV transmission.Methods: This cross-sectional study was conducted to determine the magnitude and associated factors of delayed ART initiation among PLHIV at ART Clinic, Nekemte Referral hospital, Western Ethiopia between January 1, 2020 and March 31, 2020 for the time period of January 1, 2016 to December 31, 2019. A consecutive sampling method was used to recruit 417 study subjects. The collected data were entered into Epi data version 3.1 and exported to STATA version 14 for statistical analysis. Logistic regression analysis was used to identify associated factors with delayed ART initiation among PLHIV. P-values< 0.05 were used to declare significant association.Results: A total of 417 PLHIV were included in the study. The mean age of study subjects was 33.49 (SD± 9.81) years. The majority of participants attended formal education (77%) and were urban dwellers (82%). One-third (34%) of them initiated ART delayed, beyond 7 days of confirmed HIV diagnosis. Subjects with normal nutritional status (BMI=18.5– 24.9kg/m2) (AOR=3.12, 95% CI=1.29– 7.57; P=0.012), CD4 count ≥ 351cells/mm3 (AOR=2.89, 95% CI=1.27– 6.58; P=0.011), tuberculosis (TBC) co-infection (AOR=2.76, 95% CI=1.13– 6.70; P=0.025), use of traditional treatment (AOR=4.03, 95% CI=2.03– 8.00; P< 0.001) and did not know other ART user(s) (AOR=2.86, 95% CI=1.52– 5.37; P=0.001) were significantly associated with delayed ART initiation.Conclusion: Early HIV testing mechanisms and timely linkage to HIV care by advocating “Test-and-Treat” should be strengthened.Keywords: PLHIV, antiretroviral therapy, Western EthiopiaBayisa LTadesse AReta MMGebeye EDove Medical Pressarticleplhivantiretroviral therapywestern ethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 457-465 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	plhiv antiretroviral therapy western ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	plhiv antiretroviral therapy western ethiopia Immunologic diseases. Allergy RC581-607 Bayisa L Tadesse A Reta MM Gebeye E Prevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia
description	Lami Bayisa,1 Abilo Tadesse,1 Mebratu Mitiku Reta,1 Ejigu Gebeye2 1Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Institute of Public Health, University of Gondar, Gondar, EthiopiaCorrespondence: Abilo Tadesse Email abilo.tadesse@yahoo.comBackground: Ethiopia has adopted the “Universal Test and Treat” strategy to its national policy in 2016 to put all people living with HIV/AIDS (PLHIV) on antiretroviral therapy (ART) regardless of their World Health Organization (WHO) clinical stage or CD4 cell count level. A significant percentage of PLHIV start therapy has been delayed despite the availability of ART, which results in poor treatment outcomes including HIV-related morbidity and mortality, and continued HIV transmission.Methods: This cross-sectional study was conducted to determine the magnitude and associated factors of delayed ART initiation among PLHIV at ART Clinic, Nekemte Referral hospital, Western Ethiopia between January 1, 2020 and March 31, 2020 for the time period of January 1, 2016 to December 31, 2019. A consecutive sampling method was used to recruit 417 study subjects. The collected data were entered into Epi data version 3.1 and exported to STATA version 14 for statistical analysis. Logistic regression analysis was used to identify associated factors with delayed ART initiation among PLHIV. P-values< 0.05 were used to declare significant association.Results: A total of 417 PLHIV were included in the study. The mean age of study subjects was 33.49 (SD± 9.81) years. The majority of participants attended formal education (77%) and were urban dwellers (82%). One-third (34%) of them initiated ART delayed, beyond 7 days of confirmed HIV diagnosis. Subjects with normal nutritional status (BMI=18.5– 24.9kg/m2) (AOR=3.12, 95% CI=1.29– 7.57; P=0.012), CD4 count ≥ 351cells/mm3 (AOR=2.89, 95% CI=1.27– 6.58; P=0.011), tuberculosis (TBC) co-infection (AOR=2.76, 95% CI=1.13– 6.70; P=0.025), use of traditional treatment (AOR=4.03, 95% CI=2.03– 8.00; P< 0.001) and did not know other ART user(s) (AOR=2.86, 95% CI=1.52– 5.37; P=0.001) were significantly associated with delayed ART initiation.Conclusion: Early HIV testing mechanisms and timely linkage to HIV care by advocating “Test-and-Treat” should be strengthened.Keywords: PLHIV, antiretroviral therapy, Western Ethiopia
format	article
author	Bayisa L Tadesse A Reta MM Gebeye E
author_facet	Bayisa L Tadesse A Reta MM Gebeye E
author_sort	Bayisa L
title	Prevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia
title_short	Prevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia
title_full	Prevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia
title_fullStr	Prevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia
title_full_unstemmed	Prevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia
title_sort	prevalence and factors associated with delayed initiation of antiretroviral therapy among people living with hiv in nekemte referral hospital, western ethiopia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b22f9241536c4ad983f7f50bc96c0ec1
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Prevalence and Factors Associated with Delayed Initiation of Antiretroviral Therapy Among People Living with HIV in Nekemte Referral Hospital, Western Ethiopia

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