Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19

It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and co...

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Autores principales:	Leticia Alserawan, Patricia Peñacoba, Sandra Elizabet Orozco Echevarría, Diego Castillo, Esther Ortiz, Laura Martínez-Martínez, Esther Moga Naranjo, Pere Domingo, Ivan Castellví, Cándido Juárez, Anaís Mariscal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	GDF-15 COVID-19 respiratory function inflammation biomarker Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b230f501a5b2476f8dc48ce7d0de67d0
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spelling	oai:doaj.org-article:b230f501a5b2476f8dc48ce7d0de67d02021-11-25T17:20:36ZGrowth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-1910.3390/diagnostics111119982075-4418https://doaj.org/article/b230f501a5b2476f8dc48ce7d0de67d02021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1998https://doaj.org/toc/2075-4418It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and correlated them with clinical and laboratory parameters reflecting severity in 84 patients with COVID-19, finding that GDF-15 levels were higher in both patients than in 20 healthy controls and were higher in patients with poorer respiratory function. GDF-15 levels also correlated with interleukin-6, C-reactive protein, ferritin and D-dimer levels and with neutrophilia and lymphopenia. Of all the analysed biomarkers, GDF-15 showed the best area under the receiver operating characteristics curve in identifying patients with poor respiratory function. In conclusion, our data support GDF-15 as a biomarker associated with pulmonary impairment in COVID-19 and so can potentially be useful in stratifying COVID-19 cases by severity.Leticia AlserawanPatricia PeñacobaSandra Elizabet Orozco EchevarríaDiego CastilloEsther OrtizLaura Martínez-MartínezEsther Moga NaranjoPere DomingoIvan CastellvíCándido JuárezAnaís MariscalMDPI AGarticleGDF-15COVID-19respiratory functioninflammationbiomarkerMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1998, p 1998 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GDF-15 COVID-19 respiratory function inflammation biomarker Medicine (General) R5-920
spellingShingle	GDF-15 COVID-19 respiratory function inflammation biomarker Medicine (General) R5-920 Leticia Alserawan Patricia Peñacoba Sandra Elizabet Orozco Echevarría Diego Castillo Esther Ortiz Laura Martínez-Martínez Esther Moga Naranjo Pere Domingo Ivan Castellví Cándido Juárez Anaís Mariscal Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19
description	It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and correlated them with clinical and laboratory parameters reflecting severity in 84 patients with COVID-19, finding that GDF-15 levels were higher in both patients than in 20 healthy controls and were higher in patients with poorer respiratory function. GDF-15 levels also correlated with interleukin-6, C-reactive protein, ferritin and D-dimer levels and with neutrophilia and lymphopenia. Of all the analysed biomarkers, GDF-15 showed the best area under the receiver operating characteristics curve in identifying patients with poor respiratory function. In conclusion, our data support GDF-15 as a biomarker associated with pulmonary impairment in COVID-19 and so can potentially be useful in stratifying COVID-19 cases by severity.
format	article
author	Leticia Alserawan Patricia Peñacoba Sandra Elizabet Orozco Echevarría Diego Castillo Esther Ortiz Laura Martínez-Martínez Esther Moga Naranjo Pere Domingo Ivan Castellví Cándido Juárez Anaís Mariscal
author_facet	Leticia Alserawan Patricia Peñacoba Sandra Elizabet Orozco Echevarría Diego Castillo Esther Ortiz Laura Martínez-Martínez Esther Moga Naranjo Pere Domingo Ivan Castellví Cándido Juárez Anaís Mariscal
author_sort	Leticia Alserawan
title	Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19
title_short	Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19
title_full	Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19
title_fullStr	Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19
title_full_unstemmed	Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19
title_sort	growth differentiation factor 15 (gdf-15): a novel biomarker associated with poorer respiratory function in covid-19
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b230f501a5b2476f8dc48ce7d0de67d0
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Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19

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