Comparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy

Mezgebu Legesse Habte,1 Daniel Seifu Melka,2 Maria Degef,2 MKC Menon,2 Helen Yifter,3 Teka Obsa Feyisa1 1Department of Biochemistry, School of Medicine, College of Health and Medical Sciences, Harmaya University, Harar, Ethiopia; 2Department of Medical Biochemistry, School of Medicine, College of He...

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Autores principales:	Habte ML, Melka DS, Degef M, Menon MKC, Yifter H, Feyisa TO
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Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	ck-mb hmg-coa reductase lipid profile liver enzymes statin t2dm ldh Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b233fa01295a4605889dd2a335d54a85
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spelling	oai:doaj.org-article:b233fa01295a4605889dd2a335d54a852021-12-02T11:04:37ZComparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy1178-7007https://doaj.org/article/b233fa01295a4605889dd2a335d54a852020-03-01T00:00:00Zhttps://www.dovepress.com/comparison-of-lipid-profile-liver-enzymes-creatine-kinase-and-lactate--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Mezgebu Legesse Habte,1 Daniel Seifu Melka,2 Maria Degef,2 MKC Menon,2 Helen Yifter,3 Teka Obsa Feyisa1 1Department of Biochemistry, School of Medicine, College of Health and Medical Sciences, Harmaya University, Harar, Ethiopia; 2Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Medical Endocrinology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Mezgebu Legesse HabteDepartment of Biochemistry, School of Medicine, College of Health and Medical Sciences, Harmaya University, EthiopiaTel +251 934095576Email mezgebulegesse@gmail.comBackground: Diabetes mellitus (DM) is an epidemic disease affecting millions worldwide; the majority being type 2 diabetes mellitus (T2DM). Diabetes mellitus has been shown to be an important risk factor for the development of a variety of cardiovascular diseases, which are becoming common in Ethiopia. Consequently, risk-reducing statin therapy is recommended for nearly all patients with T2DM at 40 years of age or older regardless of cholesterol level. However, some controversies exist regarding its safety.Objective: The aim of this study was to assess and compare the levels of lipid profile, liver enzymes, creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) among T2DM patients on statin therapy.Methodology: A hospital-based cross-sectional study was conducted on a total of 100 T2DM patients. The study participants were divided into four groups consisting of equal numbers of participants (n = 25). Group I, II, and III were T2DM patients who were on statin therapy for 14 days– 6 months, 6– 18 months and ˃18 months, respectively. Group IV consisted of T2DM patients who were not on statin therapy. Convenient sampling technique was implemented till the required number had been achieved. Sociodemographic data was collected by using a standardized questionnaire. Fasting blood was collected and lipid profile, liver enzymes, CK-MB, LDH and fasting blood sugar were analyzed. Data was entered using epi-data and analyzed by one way ANOVA followed by Tukey post hoc multiple comparison tests using SPSS V. 20.00. A P-value < 0.05 was considered statistically significant.Results: The mean values of total cholesterol and TAG were significantly lower among group III as compared to group I (P-values = 0.019 & 0.01). Similarly, LDL-c was significantly lower among group III as compared to group I (P = 0.022) and group IV (P = 0.027). Serum liver enzymes, CK-MB and LDH were not significantly different among the study groups (P > 0.05). The mean values of alanine aminotransferase (ALT) and AST were found within normal range while mean ALP was higher in all study groups. Fasting blood glucose value was not significantly different among the study groups, but higher than normal cut-off value in all groups.Conclusion: Statin therapy taken for a longer time has an effect in lowering total cholesterol, LDL- c and TAG in T2DM patients. Statin therapy has not brought significant change on CK-MB, LDH, liver enzymes and other parameters among T2DM patients.Keywords: CK-MB, HMG-COA reductase, lipid profile, liver enzymes, statin, T2DM, LDHHabte MLMelka DSDegef MMenon MKCYifter HFeyisa TODove Medical Pressarticleck-mbhmg-coa reductaselipid profileliver enzymesstatint2dmldhSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 763-773 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ck-mb hmg-coa reductase lipid profile liver enzymes statin t2dm ldh Specialties of internal medicine RC581-951
spellingShingle	ck-mb hmg-coa reductase lipid profile liver enzymes statin t2dm ldh Specialties of internal medicine RC581-951 Habte ML Melka DS Degef M Menon MKC Yifter H Feyisa TO Comparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy
description	Mezgebu Legesse Habte,1 Daniel Seifu Melka,2 Maria Degef,2 MKC Menon,2 Helen Yifter,3 Teka Obsa Feyisa1 1Department of Biochemistry, School of Medicine, College of Health and Medical Sciences, Harmaya University, Harar, Ethiopia; 2Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Medical Endocrinology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Mezgebu Legesse HabteDepartment of Biochemistry, School of Medicine, College of Health and Medical Sciences, Harmaya University, EthiopiaTel +251 934095576Email mezgebulegesse@gmail.comBackground: Diabetes mellitus (DM) is an epidemic disease affecting millions worldwide; the majority being type 2 diabetes mellitus (T2DM). Diabetes mellitus has been shown to be an important risk factor for the development of a variety of cardiovascular diseases, which are becoming common in Ethiopia. Consequently, risk-reducing statin therapy is recommended for nearly all patients with T2DM at 40 years of age or older regardless of cholesterol level. However, some controversies exist regarding its safety.Objective: The aim of this study was to assess and compare the levels of lipid profile, liver enzymes, creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) among T2DM patients on statin therapy.Methodology: A hospital-based cross-sectional study was conducted on a total of 100 T2DM patients. The study participants were divided into four groups consisting of equal numbers of participants (n = 25). Group I, II, and III were T2DM patients who were on statin therapy for 14 days– 6 months, 6– 18 months and ˃18 months, respectively. Group IV consisted of T2DM patients who were not on statin therapy. Convenient sampling technique was implemented till the required number had been achieved. Sociodemographic data was collected by using a standardized questionnaire. Fasting blood was collected and lipid profile, liver enzymes, CK-MB, LDH and fasting blood sugar were analyzed. Data was entered using epi-data and analyzed by one way ANOVA followed by Tukey post hoc multiple comparison tests using SPSS V. 20.00. A P-value < 0.05 was considered statistically significant.Results: The mean values of total cholesterol and TAG were significantly lower among group III as compared to group I (P-values = 0.019 & 0.01). Similarly, LDL-c was significantly lower among group III as compared to group I (P = 0.022) and group IV (P = 0.027). Serum liver enzymes, CK-MB and LDH were not significantly different among the study groups (P > 0.05). The mean values of alanine aminotransferase (ALT) and AST were found within normal range while mean ALP was higher in all study groups. Fasting blood glucose value was not significantly different among the study groups, but higher than normal cut-off value in all groups.Conclusion: Statin therapy taken for a longer time has an effect in lowering total cholesterol, LDL- c and TAG in T2DM patients. Statin therapy has not brought significant change on CK-MB, LDH, liver enzymes and other parameters among T2DM patients.Keywords: CK-MB, HMG-COA reductase, lipid profile, liver enzymes, statin, T2DM, LDH
format	article
author	Habte ML Melka DS Degef M Menon MKC Yifter H Feyisa TO
author_facet	Habte ML Melka DS Degef M Menon MKC Yifter H Feyisa TO
author_sort	Habte ML
title	Comparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy
title_short	Comparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy
title_full	Comparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy
title_fullStr	Comparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy
title_full_unstemmed	Comparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy
title_sort	comparison of lipid profile, liver enzymes, creatine kinase and lactate dehydrogenase among type ii diabetes mellitus patients on statin therapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b233fa01295a4605889dd2a335d54a85
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Comparison of Lipid Profile, Liver Enzymes, Creatine Kinase and Lactate Dehydrogenase Among Type II Diabetes Mellitus Patients on Statin Therapy

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