Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review

Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the thyroid germinal centers. To the best of our knowledge, there are only 4 reported cases of thyroid FDCS in the English literature. Herein, we present the fifth case...

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Autores principales:	Seyed-ahmad Seyed-alagheband, Mohammad-kazem Shahmoradi, Omid-Ali Adeli, Tahereh Shamsi, Maryam Sohooli, Ramin Shekouhi
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	dendritic cell sarcoma follicular dendritic cells thyroidectomy immunohistochemistry hashimoto disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b238c2128cf04babadae4d89118a50c5
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spelling	oai:doaj.org-article:b238c2128cf04babadae4d89118a50c52021-12-02T12:40:23ZFollicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review1662-657510.1159/000520485https://doaj.org/article/b238c2128cf04babadae4d89118a50c52021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520485https://doaj.org/toc/1662-6575Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the thyroid germinal centers. To the best of our knowledge, there are only 4 reported cases of thyroid FDCS in the English literature. Herein, we present the fifth case of FDCS of the thyroid gland. A 63-year-old woman presented with a painless midline neck mass, enlarging for the last 4 months. Physical examination revealed a 6-cm nonmobile, firm, multinodular thyroid mass with palpable cervical lymphadenopathy. Due to high suspicion for thyroid malignancy, the patient underwent total thyroidectomy with bilateral modified radical neck dissection. Histologic evaluations revealed sheets of storiform eosinophilic tumoral cells with prominent nucleoli containing multinucleated giant cells, and subsequent immunohistochemistry showed immunoreactivity for CD4, CD21, CD35, CD45 (LCA), and CD68. The patient was started on 6 cycles of doxorubicin, ifosfamide, and radiotherapy. She has had monthly thyroid ultrasonography and contrast-enhanced thoracoabdominal CT scan every 3 months for detecting potential recurrence and/or metastasis screening. Fortunately, 8 months after the operation, the patient is alive without any signs of local or distant metastasis.Seyed-ahmad Seyed-alaghebandMohammad-kazem ShahmoradiOmid-Ali AdeliTahereh ShamsiMaryam SohooliRamin ShekouhiKarger Publishersarticledendritic cell sarcomafollicular dendritic cellsthyroidectomyimmunohistochemistryhashimoto diseaseNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1698-1705 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dendritic cell sarcoma follicular dendritic cells thyroidectomy immunohistochemistry hashimoto disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	dendritic cell sarcoma follicular dendritic cells thyroidectomy immunohistochemistry hashimoto disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Seyed-ahmad Seyed-alagheband Mohammad-kazem Shahmoradi Omid-Ali Adeli Tahereh Shamsi Maryam Sohooli Ramin Shekouhi Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review
description	Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the thyroid germinal centers. To the best of our knowledge, there are only 4 reported cases of thyroid FDCS in the English literature. Herein, we present the fifth case of FDCS of the thyroid gland. A 63-year-old woman presented with a painless midline neck mass, enlarging for the last 4 months. Physical examination revealed a 6-cm nonmobile, firm, multinodular thyroid mass with palpable cervical lymphadenopathy. Due to high suspicion for thyroid malignancy, the patient underwent total thyroidectomy with bilateral modified radical neck dissection. Histologic evaluations revealed sheets of storiform eosinophilic tumoral cells with prominent nucleoli containing multinucleated giant cells, and subsequent immunohistochemistry showed immunoreactivity for CD4, CD21, CD35, CD45 (LCA), and CD68. The patient was started on 6 cycles of doxorubicin, ifosfamide, and radiotherapy. She has had monthly thyroid ultrasonography and contrast-enhanced thoracoabdominal CT scan every 3 months for detecting potential recurrence and/or metastasis screening. Fortunately, 8 months after the operation, the patient is alive without any signs of local or distant metastasis.
format	article
author	Seyed-ahmad Seyed-alagheband Mohammad-kazem Shahmoradi Omid-Ali Adeli Tahereh Shamsi Maryam Sohooli Ramin Shekouhi
author_facet	Seyed-ahmad Seyed-alagheband Mohammad-kazem Shahmoradi Omid-Ali Adeli Tahereh Shamsi Maryam Sohooli Ramin Shekouhi
author_sort	Seyed-ahmad Seyed-alagheband
title	Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review
title_short	Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review
title_full	Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review
title_fullStr	Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review
title_full_unstemmed	Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review
title_sort	follicular dendritic cell sarcoma of the thyroid gland in a patient with preexisting hashimoto’s thyroiditis: a rare case report with a literature review
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/b238c2128cf04babadae4d89118a50c5
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Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review

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