Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer

INTRODUCTION:Cervical cancer is a malignant infectious disease caused by Human Papilloma Virus (HPV) in the cervix. Fig and olive oil containing flavonoid has been shown to have antioxidant and anticancer activity. OBJECTIVE:This study aimed to evaluate antioxidant and cytotoxic activity of combine...

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Autores principales:	Naniek Widyaningrum, Atina Hussaana, Nesya Ayu Puspitasari
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2020
Materias:	cytotoxic antioxidant fig extract (ficus carica l.) olive oil (olea europeae l.) hela cells. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b238e1e92d914994950aec6a485b5cc3
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spelling	oai:doaj.org-article:b238e1e92d914994950aec6a485b5cc32021-11-25T13:16:36ZInvitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer2085-15452339-093X10.30659/sainsmed.v11i1.7030https://doaj.org/article/b238e1e92d914994950aec6a485b5cc32020-07-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/7030https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XINTRODUCTION:Cervical cancer is a malignant infectious disease caused by Human Papilloma Virus (HPV) in the cervix. Fig and olive oil containing flavonoid has been shown to have antioxidant and anticancer activity. OBJECTIVE:This study aimed to evaluate antioxidant and cytotoxic activity of combined Ficus carica L. and Olea europeae L. against HeLa cervical cancer cells. METHODS: This is an experimental study with a post-test only control group design. The HeLa cells were divided into 5 groups: fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1), positive control (doxorubicin). The cytotoxic and antioxidant activity were evaluated by using MTT Assay and DPPH, respectively. The cytotoxic results were analyzed using probit and antioxidant activity was analyzed by using linear regression to obtain IC50 values. RESULTS:The IC50 cytotoxic of fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1) with positive control (doxorubicin) were 13063,915 μg/mL, 679,593 μg/mL, 1562,356 μg/mL, 746,923μg/mL, 563,626 μg/mL and 13,707 μg/mL respectively. The IC50 antioxidant of fig extract, olive oil, and combination of fig extract and olive oil (3:1) was 105.9272 ppm, 23.1276 ppm, and 21,0689 ppm respectively. CONCLUSION:The combination of fig extract and olive oil (3:1) was shown to have the highest antioxidant and cytotoxic activity against HeLa cervical cancer cells.Naniek WidyaningrumAtina HussaanaNesya Ayu PuspitasariUniversitas Sultan Agung Semarangarticlecytotoxicantioxidantfig extract (ficus carica l.)olive oil (olea europeae l.)hela cells.Medicine (General)R5-920ENSains Medika, Vol 11, Iss 1, Pp 14-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytotoxic antioxidant fig extract (ficus carica l.) olive oil (olea europeae l.) hela cells. Medicine (General) R5-920
spellingShingle	cytotoxic antioxidant fig extract (ficus carica l.) olive oil (olea europeae l.) hela cells. Medicine (General) R5-920 Naniek Widyaningrum Atina Hussaana Nesya Ayu Puspitasari Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer
description	INTRODUCTION:Cervical cancer is a malignant infectious disease caused by Human Papilloma Virus (HPV) in the cervix. Fig and olive oil containing flavonoid has been shown to have antioxidant and anticancer activity. OBJECTIVE:This study aimed to evaluate antioxidant and cytotoxic activity of combined Ficus carica L. and Olea europeae L. against HeLa cervical cancer cells. METHODS: This is an experimental study with a post-test only control group design. The HeLa cells were divided into 5 groups: fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1), positive control (doxorubicin). The cytotoxic and antioxidant activity were evaluated by using MTT Assay and DPPH, respectively. The cytotoxic results were analyzed using probit and antioxidant activity was analyzed by using linear regression to obtain IC50 values. RESULTS:The IC50 cytotoxic of fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1) with positive control (doxorubicin) were 13063,915 μg/mL, 679,593 μg/mL, 1562,356 μg/mL, 746,923μg/mL, 563,626 μg/mL and 13,707 μg/mL respectively. The IC50 antioxidant of fig extract, olive oil, and combination of fig extract and olive oil (3:1) was 105.9272 ppm, 23.1276 ppm, and 21,0689 ppm respectively. CONCLUSION:The combination of fig extract and olive oil (3:1) was shown to have the highest antioxidant and cytotoxic activity against HeLa cervical cancer cells.
format	article
author	Naniek Widyaningrum Atina Hussaana Nesya Ayu Puspitasari
author_facet	Naniek Widyaningrum Atina Hussaana Nesya Ayu Puspitasari
author_sort	Naniek Widyaningrum
title	Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer
title_short	Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer
title_full	Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer
title_fullStr	Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer
title_full_unstemmed	Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer
title_sort	invitro antioxidant and cytotoxic potential of ficus carica l. and olea europeae l. against cervical cancer
publisher	Universitas Sultan Agung Semarang
publishDate	2020
url	https://doaj.org/article/b238e1e92d914994950aec6a485b5cc3
work_keys_str_mv	AT naniekwidyaningrum invitroantioxidantandcytotoxicpotentialofficuscaricalandoleaeuropeaelagainstcervicalcancer AT atinahussaana invitroantioxidantandcytotoxicpotentialofficuscaricalandoleaeuropeaelagainstcervicalcancer AT nesyaayupuspitasari invitroantioxidantandcytotoxicpotentialofficuscaricalandoleaeuropeaelagainstcervicalcancer
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Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer

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