Catalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions

The emergence of biological phosphate esters of glycerol could have been a crucial step in the origin and evolution of life on the early Earth as glycerol phosphates today play a central role in biochemistry. We investigate here the formation of the glycerol phosphates by employing various rock samp...

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Autores principales:	Maheen Gull, Matthew A. Pasek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	phosphorus phosphate esters esterification minerals catalysis origin of life Chemical technology TP1-1185 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b23ae7e2f03a42e8b28f09be8ade573b
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spelling	oai:doaj.org-article:b23ae7e2f03a42e8b28f09be8ade573b2021-11-25T17:06:36ZCatalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions10.3390/catal111113842073-4344https://doaj.org/article/b23ae7e2f03a42e8b28f09be8ade573b2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4344/11/11/1384https://doaj.org/toc/2073-4344The emergence of biological phosphate esters of glycerol could have been a crucial step in the origin and evolution of life on the early Earth as glycerol phosphates today play a central role in biochemistry. We investigate here the formation of the glycerol phosphates by employing various rock samples, salts, and minerals as potential catalysts to aid the phosphorylation process. We report the synthesis of various phosphate esters of glycerol including glycerol-1-phosphate, glycerol-2-phosphate, cyclic glycerol-monophosphate as well as various diphosphate esters. Furthermore, the decomposition rates of glycerol phosphate under mild heating were also studied while keeping the pH constant. It was observed that glycerol phosphate starts decomposing quickly under mild heating conditions into inorganic orthophosphate and pyrophosphate, and a steady state concentration of ~0.5 M of glycerol phosphate may have been reasonable in ponds with abundant glycerol, phosphate, urea, and catalytic minerals.Maheen GullMatthew A. PasekMDPI AGarticlephosphorusphosphate estersesterificationmineralscatalysisorigin of lifeChemical technologyTP1-1185ChemistryQD1-999ENCatalysts, Vol 11, Iss 1384, p 1384 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phosphorus phosphate esters esterification minerals catalysis origin of life Chemical technology TP1-1185 Chemistry QD1-999
spellingShingle	phosphorus phosphate esters esterification minerals catalysis origin of life Chemical technology TP1-1185 Chemistry QD1-999 Maheen Gull Matthew A. Pasek Catalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions
description	The emergence of biological phosphate esters of glycerol could have been a crucial step in the origin and evolution of life on the early Earth as glycerol phosphates today play a central role in biochemistry. We investigate here the formation of the glycerol phosphates by employing various rock samples, salts, and minerals as potential catalysts to aid the phosphorylation process. We report the synthesis of various phosphate esters of glycerol including glycerol-1-phosphate, glycerol-2-phosphate, cyclic glycerol-monophosphate as well as various diphosphate esters. Furthermore, the decomposition rates of glycerol phosphate under mild heating were also studied while keeping the pH constant. It was observed that glycerol phosphate starts decomposing quickly under mild heating conditions into inorganic orthophosphate and pyrophosphate, and a steady state concentration of ~0.5 M of glycerol phosphate may have been reasonable in ponds with abundant glycerol, phosphate, urea, and catalytic minerals.
format	article
author	Maheen Gull Matthew A. Pasek
author_facet	Maheen Gull Matthew A. Pasek
author_sort	Maheen Gull
title	Catalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions
title_short	Catalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions
title_full	Catalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions
title_fullStr	Catalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions
title_full_unstemmed	Catalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions
title_sort	catalytic prebiotic formation of glycerol phosphate esters and an estimation of their steady state abundance under plausible early earth conditions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b23ae7e2f03a42e8b28f09be8ade573b
work_keys_str_mv	AT maheengull catalyticprebioticformationofglycerolphosphateestersandanestimationoftheirsteadystateabundanceunderplausibleearlyearthconditions AT matthewapasek catalyticprebioticformationofglycerolphosphateestersandanestimationoftheirsteadystateabundanceunderplausibleearlyearthconditions
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Catalytic Prebiotic Formation of Glycerol Phosphate Esters and an Estimation of Their Steady State Abundance under Plausible Early Earth Conditions

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