Control of visceral leishmaniasis in latin america-a systematic review.

<h4>Background</h4>While three countries in South Asia decided to eliminate anthroponotic visceral leishmaniasis (VL) by 2015, its control in other regions seems fraught with difficulties. Is there a scope for more effective VL control in the Americas where transmission is zoonotic? We r...

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Autores principales:	Gustavo A S Romero, Marleen Boelaert
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/b23d1f78e7a642c28c8d765925e8f9a9
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spelling	oai:doaj.org-article:b23d1f78e7a642c28c8d765925e8f9a92021-11-25T06:33:43ZControl of visceral leishmaniasis in latin america-a systematic review.1935-27271935-273510.1371/journal.pntd.0000584https://doaj.org/article/b23d1f78e7a642c28c8d765925e8f9a92010-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20098726/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>While three countries in South Asia decided to eliminate anthroponotic visceral leishmaniasis (VL) by 2015, its control in other regions seems fraught with difficulties. Is there a scope for more effective VL control in the Americas where transmission is zoonotic? We reviewed the evidence on VL control strategies in Latin America-diagnosis, treatment, veterinary interventions, vector control-with respect to entomological and clinical outcomes.<h4>Methodology/principal findings</h4>We searched the electronic databases of MEDLINE, LILACS, and the Cochrane Central Register of Controlled Trials, from 1960 to November 2008 and references of selected articles. Intervention trials as well as observational studies that evaluated control strategies of VL in the Americas were included. While the use of rapid diagnostic tests for VL diagnosis seems well established, there is a striking lack of evidence from clinical trials for drug therapy and few well designed intervention studies for control of vectors or canine reservoirs.<h4>Conclusion</h4>Elimination of zoonotic VL in the Americas does not seem a realistic goal at this point given the lack of political commitment, gaps in scientific knowledge, and the weakness of case management and surveillance systems. Research priorities and current strategies should be reviewed with the aim of achieving better VL control.Gustavo A S RomeroMarleen BoelaertPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 4, Iss 1, p e584 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gustavo A S Romero Marleen Boelaert Control of visceral leishmaniasis in latin america-a systematic review.
description	<h4>Background</h4>While three countries in South Asia decided to eliminate anthroponotic visceral leishmaniasis (VL) by 2015, its control in other regions seems fraught with difficulties. Is there a scope for more effective VL control in the Americas where transmission is zoonotic? We reviewed the evidence on VL control strategies in Latin America-diagnosis, treatment, veterinary interventions, vector control-with respect to entomological and clinical outcomes.<h4>Methodology/principal findings</h4>We searched the electronic databases of MEDLINE, LILACS, and the Cochrane Central Register of Controlled Trials, from 1960 to November 2008 and references of selected articles. Intervention trials as well as observational studies that evaluated control strategies of VL in the Americas were included. While the use of rapid diagnostic tests for VL diagnosis seems well established, there is a striking lack of evidence from clinical trials for drug therapy and few well designed intervention studies for control of vectors or canine reservoirs.<h4>Conclusion</h4>Elimination of zoonotic VL in the Americas does not seem a realistic goal at this point given the lack of political commitment, gaps in scientific knowledge, and the weakness of case management and surveillance systems. Research priorities and current strategies should be reviewed with the aim of achieving better VL control.
format	article
author	Gustavo A S Romero Marleen Boelaert
author_facet	Gustavo A S Romero Marleen Boelaert
author_sort	Gustavo A S Romero
title	Control of visceral leishmaniasis in latin america-a systematic review.
title_short	Control of visceral leishmaniasis in latin america-a systematic review.
title_full	Control of visceral leishmaniasis in latin america-a systematic review.
title_fullStr	Control of visceral leishmaniasis in latin america-a systematic review.
title_full_unstemmed	Control of visceral leishmaniasis in latin america-a systematic review.
title_sort	control of visceral leishmaniasis in latin america-a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/b23d1f78e7a642c28c8d765925e8f9a9
work_keys_str_mv	AT gustavoasromero controlofvisceralleishmaniasisinlatinamericaasystematicreview AT marleenboelaert controlofvisceralleishmaniasisinlatinamericaasystematicreview
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Control of visceral leishmaniasis in latin america-a systematic review.

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