Phase-field modeling for axonal extension of nerve cells

In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tomohiro TAKAKI, Kazuya NAKAGAWA, Yusuke MORITA, Eiji NAKAMACHI
Formato:	article
Lenguaje:	EN
Publicado:	The Japan Society of Mechanical Engineers 2015
Materias:	phase-field method nerve cell axon extension neurite morphology neuroregeneration numerical model Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/b23e8511050b4b628a23c6f6ab5b33b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b23e8511050b4b628a23c6f6ab5b33b3
record_format	dspace
spelling	oai:doaj.org-article:b23e8511050b4b628a23c6f6ab5b33b32021-11-26T06:25:43ZPhase-field modeling for axonal extension of nerve cells2187-974510.1299/mej.15-00063https://doaj.org/article/b23e8511050b4b628a23c6f6ab5b33b32015-05-01T00:00:00Zhttps://www.jstage.jst.go.jp/article/mej/2/3/2_15-00063/_pdf/-char/enhttps://doaj.org/toc/2187-9745In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of nerve cell axonal extension: neurite generation, neurite contraction, and axon extension. We further determined the parameters in the phase-field equations to express the three extension stages. Finally, our results show that the modified KWC phase-field model reasonably expresses the morphologies of nerve cells and predicts the three stages of nerve cell axonal extension. Although, we employed the binary alloy solidification model as a sample model in the present phase-field simulations, this work will be extensible to relatively more realistic models for nerve cell growth.Tomohiro TAKAKIKazuya NAKAGAWAYusuke MORITAEiji NAKAMACHIThe Japan Society of Mechanical Engineersarticlephase-field methodnerve cellaxon extensionneurite morphologyneuroregenerationnumerical modelMechanical engineering and machineryTJ1-1570ENMechanical Engineering Journal, Vol 2, Iss 3, Pp 15-00063-15-00063 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	phase-field method nerve cell axon extension neurite morphology neuroregeneration numerical model Mechanical engineering and machinery TJ1-1570
spellingShingle	phase-field method nerve cell axon extension neurite morphology neuroregeneration numerical model Mechanical engineering and machinery TJ1-1570 Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI Phase-field modeling for axonal extension of nerve cells
description	In this study, we applied a modified Kobayashi-Warren-Carter (KWC) phase-field model to the neurite growth process. To confirm the applicability of this model, we observed axonal extension of PC-12D cells cultured with nerve growth factor (NGF). Based on our observations, we defined three stages of nerve cell axonal extension: neurite generation, neurite contraction, and axon extension. We further determined the parameters in the phase-field equations to express the three extension stages. Finally, our results show that the modified KWC phase-field model reasonably expresses the morphologies of nerve cells and predicts the three stages of nerve cell axonal extension. Although, we employed the binary alloy solidification model as a sample model in the present phase-field simulations, this work will be extensible to relatively more realistic models for nerve cell growth.
format	article
author	Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI
author_facet	Tomohiro TAKAKI Kazuya NAKAGAWA Yusuke MORITA Eiji NAKAMACHI
author_sort	Tomohiro TAKAKI
title	Phase-field modeling for axonal extension of nerve cells
title_short	Phase-field modeling for axonal extension of nerve cells
title_full	Phase-field modeling for axonal extension of nerve cells
title_fullStr	Phase-field modeling for axonal extension of nerve cells
title_full_unstemmed	Phase-field modeling for axonal extension of nerve cells
title_sort	phase-field modeling for axonal extension of nerve cells
publisher	The Japan Society of Mechanical Engineers
publishDate	2015
url	https://doaj.org/article/b23e8511050b4b628a23c6f6ab5b33b3
work_keys_str_mv	AT tomohirotakaki phasefieldmodelingforaxonalextensionofnervecells AT kazuyanakagawa phasefieldmodelingforaxonalextensionofnervecells AT yusukemorita phasefieldmodelingforaxonalextensionofnervecells AT eijinakamachi phasefieldmodelingforaxonalextensionofnervecells
_version_	1718409803021156352

Phase-field modeling for axonal extension of nerve cells

Ejemplares similares