Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.

Well balanced novelty seeking and exploration are fundamental behaviours for survival and are found to be dysfunctional in several psychiatric disorders. Recent studies suggest that the endocannabinoid (eCB) system is an important control system for investigatory drive. Pharmacological treatment of...

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Autores principales:	Martin Häring, Nadine Kaiser, Krisztina Monory, Beat Lutz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b2426a914fdf4062b15e035e41c3103e
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spelling	oai:doaj.org-article:b2426a914fdf4062b15e035e41c3103e2021-11-18T07:35:18ZCircuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.1932-620310.1371/journal.pone.0026617https://doaj.org/article/b2426a914fdf4062b15e035e41c3103e2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22069458/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Well balanced novelty seeking and exploration are fundamental behaviours for survival and are found to be dysfunctional in several psychiatric disorders. Recent studies suggest that the endocannabinoid (eCB) system is an important control system for investigatory drive. Pharmacological treatment of rodents with cannabinergic drugs results in altered social and object investigation. Interestingly, contradictory results have been obtained, depending on the treatment, drug concentration and experimental conditions. The cannabinoid type 1 (CB1) receptor, a central component of the eCB system, is predominantly found at the synapses of two opposing neuronal populations, i.e. on inhibitory GABAergic and excitatory glutamatergic neurons. In the present study, using different transgenic mouse lines, we aimed at investigating the impact of CB1 receptor inactivation in glutamatergic or GABAergic neurons on investigatory behaviour. We evaluated animate (interaction partner) and inanimate (object) exploratory behaviour in three different paradigms. We show that exploration was increased when CB1 receptor was deleted from cortical and striatal GABAergic neurons. No effect was observed when CB1 receptor was deleted specifically from dopamine receptor D1-expressing striatal GABAergic medium spiny neurons. In contrast, deletion of CB1 receptor from cortical glutamatergic neurons resulted in a decreased exploration. Thus, our results indicate that exploratory behaviour is accurately balanced in both, the social and non-social context, by the eCB system via CB1 receptor activation on cortical glutamatergic and GABAergic neurons. In addition, the results could explain the contradictory findings of previous pharmacological studies and could further suggest a possibility to readjust an imbalance in exploratory behaviour observed in psychiatric disorders.Martin HäringNadine KaiserKrisztina MonoryBeat LutzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e26617 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Häring Nadine Kaiser Krisztina Monory Beat Lutz Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.
description	Well balanced novelty seeking and exploration are fundamental behaviours for survival and are found to be dysfunctional in several psychiatric disorders. Recent studies suggest that the endocannabinoid (eCB) system is an important control system for investigatory drive. Pharmacological treatment of rodents with cannabinergic drugs results in altered social and object investigation. Interestingly, contradictory results have been obtained, depending on the treatment, drug concentration and experimental conditions. The cannabinoid type 1 (CB1) receptor, a central component of the eCB system, is predominantly found at the synapses of two opposing neuronal populations, i.e. on inhibitory GABAergic and excitatory glutamatergic neurons. In the present study, using different transgenic mouse lines, we aimed at investigating the impact of CB1 receptor inactivation in glutamatergic or GABAergic neurons on investigatory behaviour. We evaluated animate (interaction partner) and inanimate (object) exploratory behaviour in three different paradigms. We show that exploration was increased when CB1 receptor was deleted from cortical and striatal GABAergic neurons. No effect was observed when CB1 receptor was deleted specifically from dopamine receptor D1-expressing striatal GABAergic medium spiny neurons. In contrast, deletion of CB1 receptor from cortical glutamatergic neurons resulted in a decreased exploration. Thus, our results indicate that exploratory behaviour is accurately balanced in both, the social and non-social context, by the eCB system via CB1 receptor activation on cortical glutamatergic and GABAergic neurons. In addition, the results could explain the contradictory findings of previous pharmacological studies and could further suggest a possibility to readjust an imbalance in exploratory behaviour observed in psychiatric disorders.
format	article
author	Martin Häring Nadine Kaiser Krisztina Monory Beat Lutz
author_facet	Martin Häring Nadine Kaiser Krisztina Monory Beat Lutz
author_sort	Martin Häring
title	Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.
title_short	Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.
title_full	Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.
title_fullStr	Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.
title_full_unstemmed	Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.
title_sort	circuit specific functions of cannabinoid cb1 receptor in the balance of investigatory drive and exploration.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/b2426a914fdf4062b15e035e41c3103e
work_keys_str_mv	AT martinharing circuitspecificfunctionsofcannabinoidcb1receptorinthebalanceofinvestigatorydriveandexploration AT nadinekaiser circuitspecificfunctionsofcannabinoidcb1receptorinthebalanceofinvestigatorydriveandexploration AT krisztinamonory circuitspecificfunctionsofcannabinoidcb1receptorinthebalanceofinvestigatorydriveandexploration AT beatlutz circuitspecificfunctionsofcannabinoidcb1receptorinthebalanceofinvestigatorydriveandexploration
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Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration.

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