Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination

Abstract The tendency to ruminate (i.e., repetitive negative self-referential thoughts that perpetuate depressive mood) is associated with (a) an elevated propensity to maladaptively experience counterfactual thinking (CFT) and regret, and (b) hypo-activity of the left dorsolateral prefrontal cortex...

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Autores principales:	Jens Allaert, Rudi De Raedt, Frederik M. van der Veen, Chris Baeken, Marie-Anne Vanderhasselt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b246c1ecabd245b7b5d33d07bd8439d6
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spelling	oai:doaj.org-article:b246c1ecabd245b7b5d33d07bd8439d62021-12-02T17:51:13ZPrefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination10.1038/s41598-021-90677-72045-2322https://doaj.org/article/b246c1ecabd245b7b5d33d07bd8439d62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90677-7https://doaj.org/toc/2045-2322Abstract The tendency to ruminate (i.e., repetitive negative self-referential thoughts that perpetuate depressive mood) is associated with (a) an elevated propensity to maladaptively experience counterfactual thinking (CFT) and regret, and (b) hypo-activity of the left dorsolateral prefrontal cortex (DLPFC). The goal of this study was to investigate whether anodal transcranial direct current stimulation (tDCS) over the left DLPFC, in function of self-critical rumination tendencies, momentarily reduces counterfactual thinking and regret (assessed via self-report and psychophysiological indices). Eighty healthy participants with different levels of self-critical rumination received either anodal or sham tDCS while performing a decision making task in which they were repeatedly confronted with optimal, suboptimal, and non-optimal choice outcomes. The results showed that among rumination-prone individuals, anodal (versus sham) tDCS was associated with decreased CFT and attenuated psychophysiological reactivity to the differential choice outcomes. Conversely, among low rumination-prone individuals, anodal (versus sham) tDCS was associated with increased CFT and regret, but in absence of any effects on psychophysiological reactivity. Potential working mechanisms for these differential tDCS effects are discussed. Taken together, these results provide initial converging evidence for the adaptive effects of left prefrontal tDCS on CFT and regret to personal choice outcomes among individuals prone to engage in self-critical rumination.Jens AllaertRudi De RaedtFrederik M. van der VeenChris BaekenMarie-Anne VanderhasseltNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jens Allaert Rudi De Raedt Frederik M. van der Veen Chris Baeken Marie-Anne Vanderhasselt Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination
description	Abstract The tendency to ruminate (i.e., repetitive negative self-referential thoughts that perpetuate depressive mood) is associated with (a) an elevated propensity to maladaptively experience counterfactual thinking (CFT) and regret, and (b) hypo-activity of the left dorsolateral prefrontal cortex (DLPFC). The goal of this study was to investigate whether anodal transcranial direct current stimulation (tDCS) over the left DLPFC, in function of self-critical rumination tendencies, momentarily reduces counterfactual thinking and regret (assessed via self-report and psychophysiological indices). Eighty healthy participants with different levels of self-critical rumination received either anodal or sham tDCS while performing a decision making task in which they were repeatedly confronted with optimal, suboptimal, and non-optimal choice outcomes. The results showed that among rumination-prone individuals, anodal (versus sham) tDCS was associated with decreased CFT and attenuated psychophysiological reactivity to the differential choice outcomes. Conversely, among low rumination-prone individuals, anodal (versus sham) tDCS was associated with increased CFT and regret, but in absence of any effects on psychophysiological reactivity. Potential working mechanisms for these differential tDCS effects are discussed. Taken together, these results provide initial converging evidence for the adaptive effects of left prefrontal tDCS on CFT and regret to personal choice outcomes among individuals prone to engage in self-critical rumination.
format	article
author	Jens Allaert Rudi De Raedt Frederik M. van der Veen Chris Baeken Marie-Anne Vanderhasselt
author_facet	Jens Allaert Rudi De Raedt Frederik M. van der Veen Chris Baeken Marie-Anne Vanderhasselt
author_sort	Jens Allaert
title	Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination
title_short	Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination
title_full	Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination
title_fullStr	Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination
title_full_unstemmed	Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination
title_sort	prefrontal tdcs attenuates counterfactual thinking in female individuals prone to self-critical rumination
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b246c1ecabd245b7b5d33d07bd8439d6
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Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination

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