Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness

Abstract In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: S. Schultz-Cherry, R. J. Webby, R. G. Webster, A. Kelso, I. G. Barr, J. W. McCauley, R. S. Daniels, D. Wang, Y. Shu, E. Nobusawa, S. Itamura, M. Tashiro, Y. Harada, S. Watanabe, T. Odagiri, Z. Ye, G. Grohmann, R. Harvey, O. Engelhardt, D. Smith, K. Hamilton, F. Claes, G. Dauphin
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Acceso en línea:https://doaj.org/article/b24b1c8460df462991d8658709d280fc
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Abstract In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.