Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness

Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness

Abstract In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have...

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Autores principales: S. Schultz-Cherry, R. J. Webby, R. G. Webster, A. Kelso, I. G. Barr, J. W. McCauley, R. S. Daniels, D. Wang, Y. Shu, E. Nobusawa, S. Itamura, M. Tashiro, Y. Harada, S. Watanabe, T. Odagiri, Z. Ye, G. Grohmann, R. Harvey, O. Engelhardt, D. Smith, K. Hamilton, F. Claes, G. Dauphin
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/b24b1c8460df462991d8658709d280fc
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spelling oai:doaj.org-article:b24b1c8460df462991d8658709d280fc2021-11-15T15:47:04ZInfluenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness10.1128/mBio.02430-142150-7511https://doaj.org/article/b24b1c8460df462991d8658709d280fc2014-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02430-14https://doaj.org/toc/2150-7511Abstract In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.S. Schultz-CherryR. J. WebbyR. G. WebsterA. KelsoI. G. BarrJ. W. McCauleyR. S. DanielsD. WangY. ShuE. NobusawaS. ItamuraM. TashiroY. HaradaS. WatanabeT. OdagiriZ. YeG. GrohmannR. HarveyO. EngelhardtD. SmithK. HamiltonF. ClaesG. DauphinAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 6 (2014)
institution DOAJ
collection DOAJ
language EN
topic Microbiology
QR1-502
spellingShingle Microbiology
QR1-502
S. Schultz-Cherry
R. J. Webby
R. G. Webster
A. Kelso
I. G. Barr
J. W. McCauley
R. S. Daniels
D. Wang
Y. Shu
E. Nobusawa
S. Itamura
M. Tashiro
Y. Harada
S. Watanabe
T. Odagiri
Z. Ye
G. Grohmann
R. Harvey
O. Engelhardt
D. Smith
K. Hamilton
F. Claes
G. Dauphin
Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
description Abstract In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.
format article
author S. Schultz-Cherry
R. J. Webby
R. G. Webster
A. Kelso
I. G. Barr
J. W. McCauley
R. S. Daniels
D. Wang
Y. Shu
E. Nobusawa
S. Itamura
M. Tashiro
Y. Harada
S. Watanabe
T. Odagiri
Z. Ye
G. Grohmann
R. Harvey
O. Engelhardt
D. Smith
K. Hamilton
F. Claes
G. Dauphin
author_facet S. Schultz-Cherry
R. J. Webby
R. G. Webster
A. Kelso
I. G. Barr
J. W. McCauley
R. S. Daniels
D. Wang
Y. Shu
E. Nobusawa
S. Itamura
M. Tashiro
Y. Harada
S. Watanabe
T. Odagiri
Z. Ye
G. Grohmann
R. Harvey
O. Engelhardt
D. Smith
K. Hamilton
F. Claes
G. Dauphin
author_sort S. Schultz-Cherry
title Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_short Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_full Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_fullStr Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_full_unstemmed Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
title_sort influenza gain-of-function experiments: their role in vaccine virus recommendation and pandemic preparedness
publisher American Society for Microbiology
publishDate 2014
url https://doaj.org/article/b24b1c8460df462991d8658709d280fc
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