Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity

Abstract Fibromyalgia (FM) as Fibromyalgia and Electromagnetic Sensitivity (IEI-EMF) are a chronic and systemic syndrome. The main symptom is represented by strong and widespread pain in the musculoskeletal system. The exact causes that lead to the development of FM and IEI-EMF are still unknown. In...

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Autores principales:	Cristina Piras, Stella Conte, Monica Pibiri, Giacomo Rao, Sandro Muntoni, Vera Piera Leoni, Gabriele Finco, Luigi Atzori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b24cf23d8eb74fef8b491f5c7aa5497d
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spelling	oai:doaj.org-article:b24cf23d8eb74fef8b491f5c7aa5497d2021-12-02T11:42:13ZMetabolomics and psychological features in fibromyalgia and electromagnetic sensitivity10.1038/s41598-020-76876-82045-2322https://doaj.org/article/b24cf23d8eb74fef8b491f5c7aa5497d2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76876-8https://doaj.org/toc/2045-2322Abstract Fibromyalgia (FM) as Fibromyalgia and Electromagnetic Sensitivity (IEI-EMF) are a chronic and systemic syndrome. The main symptom is represented by strong and widespread pain in the musculoskeletal system. The exact causes that lead to the development of FM and IEI-EMF are still unknown. Interestingly, the proximity to electrical and electromagnetic devices seems to trigger and/or amplify the symptoms. We investigated the blood plasma metabolome in IEI-EMF and healthy subjects using 1H NMR spectroscopy coupled with multivariate statistical analysis. All the individuals were subjected to tests for the evaluation of psychological and physical features. No significant differences between IEI-EMF and controls relative to personality aspects, Locus of Control, and anxiety were found. Multivariate statistical analysis on the metabolites identified by NMR analysis allowed the identification of a distinct metabolic profile between IEI-EMF and healthy subjects. IEI-EMF were characterized by higher levels of glycine and pyroglutamate, and lower levels of 2-hydroxyisocaproate, choline, glutamine, and isoleucine compared to healthy subjects. These metabolites are involved in several metabolic pathways mainly related to oxidative stress defense, pain mechanisms, and muscle metabolism. The results here obtained highlight possible physiopathological mechanisms in IEI-EMF patients to be better defined.Cristina PirasStella ConteMonica PibiriGiacomo RaoSandro MuntoniVera Piera LeoniGabriele FincoLuigi AtzoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristina Piras Stella Conte Monica Pibiri Giacomo Rao Sandro Muntoni Vera Piera Leoni Gabriele Finco Luigi Atzori Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity
description	Abstract Fibromyalgia (FM) as Fibromyalgia and Electromagnetic Sensitivity (IEI-EMF) are a chronic and systemic syndrome. The main symptom is represented by strong and widespread pain in the musculoskeletal system. The exact causes that lead to the development of FM and IEI-EMF are still unknown. Interestingly, the proximity to electrical and electromagnetic devices seems to trigger and/or amplify the symptoms. We investigated the blood plasma metabolome in IEI-EMF and healthy subjects using 1H NMR spectroscopy coupled with multivariate statistical analysis. All the individuals were subjected to tests for the evaluation of psychological and physical features. No significant differences between IEI-EMF and controls relative to personality aspects, Locus of Control, and anxiety were found. Multivariate statistical analysis on the metabolites identified by NMR analysis allowed the identification of a distinct metabolic profile between IEI-EMF and healthy subjects. IEI-EMF were characterized by higher levels of glycine and pyroglutamate, and lower levels of 2-hydroxyisocaproate, choline, glutamine, and isoleucine compared to healthy subjects. These metabolites are involved in several metabolic pathways mainly related to oxidative stress defense, pain mechanisms, and muscle metabolism. The results here obtained highlight possible physiopathological mechanisms in IEI-EMF patients to be better defined.
format	article
author	Cristina Piras Stella Conte Monica Pibiri Giacomo Rao Sandro Muntoni Vera Piera Leoni Gabriele Finco Luigi Atzori
author_facet	Cristina Piras Stella Conte Monica Pibiri Giacomo Rao Sandro Muntoni Vera Piera Leoni Gabriele Finco Luigi Atzori
author_sort	Cristina Piras
title	Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity
title_short	Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity
title_full	Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity
title_fullStr	Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity
title_full_unstemmed	Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity
title_sort	metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b24cf23d8eb74fef8b491f5c7aa5497d
work_keys_str_mv	AT cristinapiras metabolomicsandpsychologicalfeaturesinfibromyalgiaandelectromagneticsensitivity AT stellaconte metabolomicsandpsychologicalfeaturesinfibromyalgiaandelectromagneticsensitivity AT monicapibiri metabolomicsandpsychologicalfeaturesinfibromyalgiaandelectromagneticsensitivity AT giacomorao metabolomicsandpsychologicalfeaturesinfibromyalgiaandelectromagneticsensitivity AT sandromuntoni metabolomicsandpsychologicalfeaturesinfibromyalgiaandelectromagneticsensitivity AT verapieraleoni metabolomicsandpsychologicalfeaturesinfibromyalgiaandelectromagneticsensitivity AT gabrielefinco metabolomicsandpsychologicalfeaturesinfibromyalgiaandelectromagneticsensitivity AT luigiatzori metabolomicsandpsychologicalfeaturesinfibromyalgiaandelectromagneticsensitivity
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Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity

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