Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon

Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5’ and 3’ UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3...

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Autores principales:	Huguette Simo Tchetgna, Francine Sado Yousseu, Basile Kamgang, Armel Tedjou, Philip J. McCall, Charles S. Wondji
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/b24d1ab20fbd41c2aa68defe6a890460
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spelling	oai:doaj.org-article:b24d1ab20fbd41c2aa68defe6a8904602021-11-11T09:25:06ZConcurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon1935-27271935-2735https://doaj.org/article/b24d1ab20fbd41c2aa68defe6a8904602021-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568189/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5’ and 3’ UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region. Author summary Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections by Polymerase chain reaction. In total, 12.8% (41/320) of cases examined were infected by dengue virus. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.Huguette Simo TchetgnaFrancine Sado YousseuBasile KamgangArmel TedjouPhilip J. McCallCharles S. WondjiPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J. McCall Charles S. Wondji Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon
description	Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5’ and 3’ UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region. Author summary Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections by Polymerase chain reaction. In total, 12.8% (41/320) of cases examined were infected by dengue virus. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.
format	article
author	Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J. McCall Charles S. Wondji
author_facet	Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J. McCall Charles S. Wondji
author_sort	Huguette Simo Tchetgna
title	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon
title_short	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon
title_full	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon
title_fullStr	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon
title_full_unstemmed	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon
title_sort	concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in cameroon
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b24d1ab20fbd41c2aa68defe6a890460
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Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon

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