Periorbital edema secondary to imatinib mesylate

Collin M McClelland, George J Harocopos, Philip L CusterSchool of Medicine, Washington University, St. Louis, MO, USAAbstract: Imatinib mesylate (Gleevec&reg;) is a well-established pharmacologic treatment for all phases of chronic myeloid leukemia and for advanced gastrointestinal stromal t...

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Autores principales:	Collin M McClelland, George J Harocopos, Philip L Custer
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b24ecbe6ffba41f2b443f72352e293e2
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spelling	oai:doaj.org-article:b24ecbe6ffba41f2b443f72352e293e22021-12-02T06:59:29ZPeriorbital edema secondary to imatinib mesylate1177-54671177-5483https://doaj.org/article/b24ecbe6ffba41f2b443f72352e293e22010-05-01T00:00:00Zhttp://www.dovepress.com/periorbital-edema-secondary-to-imatinib-mesylate-a4421https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Collin M McClelland, George J Harocopos, Philip L CusterSchool of Medicine, Washington University, St. Louis, MO, USAAbstract: Imatinib mesylate (Gleevec&reg;) is a well-established pharmacologic treatment for all phases of chronic myeloid leukemia and for advanced gastrointestinal stromal tumors (GISTs). Edema-related side effects are relatively common in imatinib therapy with the periocular skin representing one of the most common sites for localized edema. While the adverse effect of periorbital edema with imatinib is well documented in the oncology literature, there is limited reference to this common reaction in the ophthalmology literature. We report two patients with upper eyelid edema associated with imatinib therapy who required surgical intervention to ameliorate significant visual field obstruction. We highlight the details of each case including the histopathologic findings of excised redundant skin followed by a thorough review of the literature on imatinib related periorbital edema.Keywords: imatinib mesylate, gleevec, edema, periorbital edema, tyrosine kinase inhibitor Collin M McClellandGeorge J HarocoposPhilip L CusterDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 427-431 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Collin M McClelland George J Harocopos Philip L Custer Periorbital edema secondary to imatinib mesylate
description	Collin M McClelland, George J Harocopos, Philip L CusterSchool of Medicine, Washington University, St. Louis, MO, USAAbstract: Imatinib mesylate (Gleevec&reg;) is a well-established pharmacologic treatment for all phases of chronic myeloid leukemia and for advanced gastrointestinal stromal tumors (GISTs). Edema-related side effects are relatively common in imatinib therapy with the periocular skin representing one of the most common sites for localized edema. While the adverse effect of periorbital edema with imatinib is well documented in the oncology literature, there is limited reference to this common reaction in the ophthalmology literature. We report two patients with upper eyelid edema associated with imatinib therapy who required surgical intervention to ameliorate significant visual field obstruction. We highlight the details of each case including the histopathologic findings of excised redundant skin followed by a thorough review of the literature on imatinib related periorbital edema.Keywords: imatinib mesylate, gleevec, edema, periorbital edema, tyrosine kinase inhibitor
format	article
author	Collin M McClelland George J Harocopos Philip L Custer
author_facet	Collin M McClelland George J Harocopos Philip L Custer
author_sort	Collin M McClelland
title	Periorbital edema secondary to imatinib mesylate
title_short	Periorbital edema secondary to imatinib mesylate
title_full	Periorbital edema secondary to imatinib mesylate
title_fullStr	Periorbital edema secondary to imatinib mesylate
title_full_unstemmed	Periorbital edema secondary to imatinib mesylate
title_sort	periorbital edema secondary to imatinib mesylate
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/b24ecbe6ffba41f2b443f72352e293e2
work_keys_str_mv	AT collinmmcclelland periorbitaledemasecondarytoimatinibmesylate AT georgejharocopos periorbitaledemasecondarytoimatinibmesylate AT philiplcuster periorbitaledemasecondarytoimatinibmesylate
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Periorbital edema secondary to imatinib mesylate

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