The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans
G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological processes. It is commonly agreed that G4 unwinding helicases play key roles in G4 metabolism and function, and these processes are closely r...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:b24ecf376d504861b34d4946841dfacc2021-12-01T13:48:25ZThe Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans2296-889X10.3389/fmolb.2021.783889https://doaj.org/article/b24ecf376d504861b34d4946841dfacc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.783889/fullhttps://doaj.org/toc/2296-889XG-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological processes. It is commonly agreed that G4 unwinding helicases play key roles in G4 metabolism and function, and these processes are closely related to physiological and pathological processes. In recent years, more and more functional and mechanistic details of G4 helicases have been discovered; therefore, it is necessary to carefully sort out the current research efforts. Here, we provide a systematic summary of G4 unwinding helicases from the perspective of functions and molecular mechanisms. First, we provide a general introduction about helicases and G4s. Next, we comprehensively summarize G4 unfolding helicases in humans and their proposed cellular functions. Then, we review their study methods and molecular mechanisms. Finally, we share our perspective on further prospects. We believe this review will provide opportunities for researchers to reach the frontiers in the functions and molecular mechanisms of human G4 unwinding helicases.Yang LiuYang LiuYang LiuYang LiuXinting ZhuKejia WangKejia WangKejia WangBo ZhangShuyi QiuShuyi QiuShuyi QiuFrontiers Media S.A.articleG-quadruplexhelicasegenetic diseaseage-related diseasescancerBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
G-quadruplex helicase genetic disease age-related diseases cancer Biology (General) QH301-705.5 |
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G-quadruplex helicase genetic disease age-related diseases cancer Biology (General) QH301-705.5 Yang Liu Yang Liu Yang Liu Yang Liu Xinting Zhu Kejia Wang Kejia Wang Kejia Wang Bo Zhang Shuyi Qiu Shuyi Qiu Shuyi Qiu The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans |
| description |
G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological processes. It is commonly agreed that G4 unwinding helicases play key roles in G4 metabolism and function, and these processes are closely related to physiological and pathological processes. In recent years, more and more functional and mechanistic details of G4 helicases have been discovered; therefore, it is necessary to carefully sort out the current research efforts. Here, we provide a systematic summary of G4 unwinding helicases from the perspective of functions and molecular mechanisms. First, we provide a general introduction about helicases and G4s. Next, we comprehensively summarize G4 unfolding helicases in humans and their proposed cellular functions. Then, we review their study methods and molecular mechanisms. Finally, we share our perspective on further prospects. We believe this review will provide opportunities for researchers to reach the frontiers in the functions and molecular mechanisms of human G4 unwinding helicases. |
| format |
article |
| author |
Yang Liu Yang Liu Yang Liu Yang Liu Xinting Zhu Kejia Wang Kejia Wang Kejia Wang Bo Zhang Shuyi Qiu Shuyi Qiu Shuyi Qiu |
| author_facet |
Yang Liu Yang Liu Yang Liu Yang Liu Xinting Zhu Kejia Wang Kejia Wang Kejia Wang Bo Zhang Shuyi Qiu Shuyi Qiu Shuyi Qiu |
| author_sort |
Yang Liu |
| title |
The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans |
| title_short |
The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans |
| title_full |
The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans |
| title_fullStr |
The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans |
| title_full_unstemmed |
The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans |
| title_sort |
cellular functions and molecular mechanisms of g-quadruplex unwinding helicases in humans |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/b24ecf376d504861b34d4946841dfacc |
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