Trichomonas vaginalis follow-up and persistence in Colombian women

Abstract Trichomonas vaginalis (TV), the most common non-viral sexually-transmitted infection is considered a neglected infection and its epidemiology is not well known. This study determined TV-infection dynamics in a retrospective cohort of Colombian women and evaluated associations between risk f...

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Autores principales:	Lauren Hernández-Buelvas, Milena Camargo, Ricardo Sánchez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b25235c04e144aaabf73784f9450739f
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spelling	oai:doaj.org-article:b25235c04e144aaabf73784f9450739f2021-11-21T12:23:11ZTrichomonas vaginalis follow-up and persistence in Colombian women10.1038/s41598-021-02135-z2045-2322https://doaj.org/article/b25235c04e144aaabf73784f9450739f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02135-zhttps://doaj.org/toc/2045-2322Abstract Trichomonas vaginalis (TV), the most common non-viral sexually-transmitted infection is considered a neglected infection and its epidemiology is not well known. This study determined TV-infection dynamics in a retrospective cohort of Colombian women and evaluated associations between risk factors and TV-outcome. TV was identified by PCR. Cox proportional risk models were used for evaluating the relationship between TV-outcome (infection, clearance and persistence) and risk factors (sexually-transmitted infections and sociodemographic characteristics). Two hundred and sixty-four women were included in the study; 26.1% had TV at the start of the study, 40.9% suffered at least one episode of infection and 13.0% suffered more than one episode of TV during the study. Women suffering HPV had a greater risk of TV-infection (aHR 1.59), high viral-load (> 102) for HPV-16 being related to a greater risk of persistent parasite infection; a high viral load (> 102) for HPV-18 and -33 was related to a lower probability of TV-clearance. Ethnicity (afrodescendent/indigenous people: aHR 5.11) and having had more than two sexual partners (aHR 1.94) were related to greater risk of infection, contrasting with women having a background of abortions and lower probability of having TV (aHR 0.50). Women aged 35- to 49-years-old (aHR 2.08), increased years of sexual activity (aHR 1.10), multiple sexual partners (aHR 8.86) and multiparous women (aHR 3.85) led to a greater probability of persistence. Women whose cervical findings worsened had a 9.99 greater probability of TV-persistence. TV distribution was high in the study population; its coexistence with HPV and other risk factors influenced parasite infection dynamics. The results suggested that routine TV detection should be considered regarding populations at risk of infection.Lauren Hernández-BuelvasMilena CamargoRicardo SánchezManuel Elkin PatarroyoManuel Alfonso PatarroyoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lauren Hernández-Buelvas Milena Camargo Ricardo Sánchez Manuel Elkin Patarroyo Manuel Alfonso Patarroyo Trichomonas vaginalis follow-up and persistence in Colombian women
description	Abstract Trichomonas vaginalis (TV), the most common non-viral sexually-transmitted infection is considered a neglected infection and its epidemiology is not well known. This study determined TV-infection dynamics in a retrospective cohort of Colombian women and evaluated associations between risk factors and TV-outcome. TV was identified by PCR. Cox proportional risk models were used for evaluating the relationship between TV-outcome (infection, clearance and persistence) and risk factors (sexually-transmitted infections and sociodemographic characteristics). Two hundred and sixty-four women were included in the study; 26.1% had TV at the start of the study, 40.9% suffered at least one episode of infection and 13.0% suffered more than one episode of TV during the study. Women suffering HPV had a greater risk of TV-infection (aHR 1.59), high viral-load (> 102) for HPV-16 being related to a greater risk of persistent parasite infection; a high viral load (> 102) for HPV-18 and -33 was related to a lower probability of TV-clearance. Ethnicity (afrodescendent/indigenous people: aHR 5.11) and having had more than two sexual partners (aHR 1.94) were related to greater risk of infection, contrasting with women having a background of abortions and lower probability of having TV (aHR 0.50). Women aged 35- to 49-years-old (aHR 2.08), increased years of sexual activity (aHR 1.10), multiple sexual partners (aHR 8.86) and multiparous women (aHR 3.85) led to a greater probability of persistence. Women whose cervical findings worsened had a 9.99 greater probability of TV-persistence. TV distribution was high in the study population; its coexistence with HPV and other risk factors influenced parasite infection dynamics. The results suggested that routine TV detection should be considered regarding populations at risk of infection.
format	article
author	Lauren Hernández-Buelvas Milena Camargo Ricardo Sánchez Manuel Elkin Patarroyo Manuel Alfonso Patarroyo
author_facet	Lauren Hernández-Buelvas Milena Camargo Ricardo Sánchez Manuel Elkin Patarroyo Manuel Alfonso Patarroyo
author_sort	Lauren Hernández-Buelvas
title	Trichomonas vaginalis follow-up and persistence in Colombian women
title_short	Trichomonas vaginalis follow-up and persistence in Colombian women
title_full	Trichomonas vaginalis follow-up and persistence in Colombian women
title_fullStr	Trichomonas vaginalis follow-up and persistence in Colombian women
title_full_unstemmed	Trichomonas vaginalis follow-up and persistence in Colombian women
title_sort	trichomonas vaginalis follow-up and persistence in colombian women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b25235c04e144aaabf73784f9450739f
work_keys_str_mv	AT laurenhernandezbuelvas trichomonasvaginalisfollowupandpersistenceincolombianwomen AT milenacamargo trichomonasvaginalisfollowupandpersistenceincolombianwomen AT ricardosanchez trichomonasvaginalisfollowupandpersistenceincolombianwomen AT manuelelkinpatarroyo trichomonasvaginalisfollowupandpersistenceincolombianwomen AT manuelalfonsopatarroyo trichomonasvaginalisfollowupandpersistenceincolombianwomen
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Trichomonas vaginalis follow-up and persistence in Colombian women

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