Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.

The family of type I interferons (IFN), which consists of several IFN-α and one IFN-β, are produced not only after stimulation by viruses, but also after infection with non-viral pathogens. In the course of bacterial infections, these cytokines could be beneficial or detrimental. IFN-β is the primar...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Evgenia Solodova, Jadwiga Jablonska, Siegfried Weiss, Stefan Lienenklaus
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b254104042ac4cb6a9ff502f8d269f67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b254104042ac4cb6a9ff502f8d269f67
record_format	dspace
spelling	oai:doaj.org-article:b254104042ac4cb6a9ff502f8d269f672021-11-18T06:55:58ZProduction of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.1932-620310.1371/journal.pone.0018543https://doaj.org/article/b254104042ac4cb6a9ff502f8d269f672011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21494554/?tool=EBIhttps://doaj.org/toc/1932-6203The family of type I interferons (IFN), which consists of several IFN-α and one IFN-β, are produced not only after stimulation by viruses, but also after infection with non-viral pathogens. In the course of bacterial infections, these cytokines could be beneficial or detrimental. IFN-β is the primary member of type I IFN that initiates a cascade of IFN-α production. Here we addressed the question which cells are responsible for IFN-β expression after infection with the intracellular pathogen Listeria monocytogenes by using a genetic approach. By means of newly established reporter mice, maximum of IFN-β expression was observed at 24 hours post infection in spleen and, surprisingly, 48 hours post infection in colonized cervical and inguinal lymph nodes. Colonization of lymph nodes was independent of the type I IFN signaling, as well as bacterial dose and strain. Using cell specific reporter function and conditional deletions we could define cells expressing LysM as the major IFN-β producers, with cells formerly defined as Tip-DCs being the highest. Neutrophilic granulocytes, dendritic cells and plasmacytoid dendritic cells did not significantly contribute to type I IFN production.Evgenia SolodovaJadwiga JablonskaSiegfried WeissStefan LienenklausPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18543 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Evgenia Solodova Jadwiga Jablonska Siegfried Weiss Stefan Lienenklaus Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
description	The family of type I interferons (IFN), which consists of several IFN-α and one IFN-β, are produced not only after stimulation by viruses, but also after infection with non-viral pathogens. In the course of bacterial infections, these cytokines could be beneficial or detrimental. IFN-β is the primary member of type I IFN that initiates a cascade of IFN-α production. Here we addressed the question which cells are responsible for IFN-β expression after infection with the intracellular pathogen Listeria monocytogenes by using a genetic approach. By means of newly established reporter mice, maximum of IFN-β expression was observed at 24 hours post infection in spleen and, surprisingly, 48 hours post infection in colonized cervical and inguinal lymph nodes. Colonization of lymph nodes was independent of the type I IFN signaling, as well as bacterial dose and strain. Using cell specific reporter function and conditional deletions we could define cells expressing LysM as the major IFN-β producers, with cells formerly defined as Tip-DCs being the highest. Neutrophilic granulocytes, dendritic cells and plasmacytoid dendritic cells did not significantly contribute to type I IFN production.
format	article
author	Evgenia Solodova Jadwiga Jablonska Siegfried Weiss Stefan Lienenklaus
author_facet	Evgenia Solodova Jadwiga Jablonska Siegfried Weiss Stefan Lienenklaus
author_sort	Evgenia Solodova
title	Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
title_short	Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
title_full	Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
title_fullStr	Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
title_full_unstemmed	Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
title_sort	production of ifn-β during listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/b254104042ac4cb6a9ff502f8d269f67
work_keys_str_mv	AT evgeniasolodova productionofifnbduringlisteriamonocytogenesinfectionisrestrictedtomonocytemacrophagelineage AT jadwigajablonska productionofifnbduringlisteriamonocytogenesinfectionisrestrictedtomonocytemacrophagelineage AT siegfriedweiss productionofifnbduringlisteriamonocytogenesinfectionisrestrictedtomonocytemacrophagelineage AT stefanlienenklaus productionofifnbduringlisteriamonocytogenesinfectionisrestrictedtomonocytemacrophagelineage
_version_	1718424188656549888

Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.

Ejemplares similares