Vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus

Aims. To determine vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus (T2DM). Materials and Methods. Study included 143 patients with systemic atherosclerosis, 40 of them also suffered from T2DM. We applied laser Doppler flowmetry (LDF) to evaluate vas...

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Auteurs principaux:	O V Kamenskaya, I Yu Loginova, Asya Stanislavovna Klinkova, Andrey Anatol'evich Karpenko
Format:	article
Langue:	EN RU
Publié:	Endocrinology Research Centre 2013
Sujets:	systemic atherosclerosis type 2 diabetes mellitus microcirculation Nutritional diseases. Deficiency diseases RC620-627
Accès en ligne:	https://doaj.org/article/b256918a467f4d2590a872fba36092c6
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id	oai:doaj.org-article:b256918a467f4d2590a872fba36092c6
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spelling	oai:doaj.org-article:b256918a467f4d2590a872fba36092c62021-11-14T09:00:18ZVascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-3601https://doaj.org/article/b256918a467f4d2590a872fba36092c62013-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3601https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. To determine vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus (T2DM). Materials and Methods. Study included 143 patients with systemic atherosclerosis, 40 of them also suffered from T2DM. We applied laser Doppler flowmetry (LDF) to evaluate vascular channel reserves and transcranial spectrometry to assess cerebral oxygenation status. Results. We found that 60% of patients with systemic atherosclerosis and T2DM show microcirculation parameters below critical level, which indicates failure of collateral circulation. This group also showed lower efficiency of cerebral perfusion and more pronounced vascular constriction in response to functional load as compared to diabetes-negative controls. Conclusion. Patients with T2DM, accompanied with systemic atherosclerosis showed lower circulation efficiency and more pronounced autonomous dysregulation of cerebral circulation against patients without diabetes mellitus.O V KamenskayaI Yu LoginovaAsya Stanislavovna KlinkovaAndrey Anatol'evich KarpenkoEndocrinology Research Centrearticlesystemic atherosclerosistype 2 diabetes mellitusmicrocirculationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 1, Pp 78-82 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	systemic atherosclerosis type 2 diabetes mellitus microcirculation Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	systemic atherosclerosis type 2 diabetes mellitus microcirculation Nutritional diseases. Deficiency diseases RC620-627 O V Kamenskaya I Yu Loginova Asya Stanislavovna Klinkova Andrey Anatol'evich Karpenko Vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus
description	Aims. To determine vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus (T2DM). Materials and Methods. Study included 143 patients with systemic atherosclerosis, 40 of them also suffered from T2DM. We applied laser Doppler flowmetry (LDF) to evaluate vascular channel reserves and transcranial spectrometry to assess cerebral oxygenation status. Results. We found that 60% of patients with systemic atherosclerosis and T2DM show microcirculation parameters below critical level, which indicates failure of collateral circulation. This group also showed lower efficiency of cerebral perfusion and more pronounced vascular constriction in response to functional load as compared to diabetes-negative controls. Conclusion. Patients with T2DM, accompanied with systemic atherosclerosis showed lower circulation efficiency and more pronounced autonomous dysregulation of cerebral circulation against patients without diabetes mellitus.
format	article
author	O V Kamenskaya I Yu Loginova Asya Stanislavovna Klinkova Andrey Anatol'evich Karpenko
author_facet	O V Kamenskaya I Yu Loginova Asya Stanislavovna Klinkova Andrey Anatol'evich Karpenko
author_sort	O V Kamenskaya
title	Vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus
title_short	Vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus
title_full	Vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus
title_fullStr	Vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus
title_full_unstemmed	Vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus
title_sort	vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/b256918a467f4d2590a872fba36092c6
work_keys_str_mv	AT ovkamenskaya vascularchannelreservesinpatientswithsystemicatherosclerosisandtype2diabetesmellitus AT iyuloginova vascularchannelreservesinpatientswithsystemicatherosclerosisandtype2diabetesmellitus AT asyastanislavovnaklinkova vascularchannelreservesinpatientswithsystemicatherosclerosisandtype2diabetesmellitus AT andreyanatolevichkarpenko vascularchannelreservesinpatientswithsystemicatherosclerosisandtype2diabetesmellitus
_version_	1718429605555077120

Vascular channel reserves in patients with systemic atherosclerosis and type 2 diabetes mellitus

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