Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection

Abstract Early bacterial infection (BI) identification in resource-limiting Emergency Departments (ED) is challenging, especially in low- and middle-income counties (LMIC). Misdiagnosis predisposes to antibiotic overuse and propagates antimicrobial resistance. This study evaluates new emerging bioma...

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Autores principales:	Toh Leong Tan, Christabel Wan-li Kang, Kai Shen Ooi, Swee Thian Tan, Nurul Saadah Ahmad, Dian Nasriana Nasuruddin, Azlin Ithnin, Khaizurin Tajul Arifin, Lee Yook Heng, Nurul Izzaty Hassan, Kok Beng Gan, Hui-min Neoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b25a115748d54f5a84a791ac14fc1a4e
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spelling	oai:doaj.org-article:b25a115748d54f5a84a791ac14fc1a4e2021-12-02T18:25:02ZComparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection10.1038/s41598-021-90894-02045-2322https://doaj.org/article/b25a115748d54f5a84a791ac14fc1a4e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90894-0https://doaj.org/toc/2045-2322Abstract Early bacterial infection (BI) identification in resource-limiting Emergency Departments (ED) is challenging, especially in low- and middle-income counties (LMIC). Misdiagnosis predisposes to antibiotic overuse and propagates antimicrobial resistance. This study evaluates new emerging biomarkers, secretory phospholipase A2 group IIA (sPLA2-IIA) and compares with other biomarkers on their performance characteristic of BI detection in Malaysia, an LMIC. A prospective cohort study was conducted involving 151 consecutive patients admitted to the ED. A single measurement was taken upon patient arrival in ED and was analysed for serum levels of sPLA2-IIA, high-sensitive C-reactive protein (CRP), procalcitonin (PCT), neutrophil percentage (N%), and lactate. All biomarkers’ performance was compared for the outcomes using area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity. The performance of sPLA2-IIA (AUROC 0.93 [95% CI: 0.89–0.97]; Sn 80% [95% CI: 72–87]; Sp 94% [95% CI: 81–89]) was the highest among all. It was comparable with high-sensitive CRP (AUROC 0.93 [95% CI: 0.88–0.97]; Sn 75% [95% CI: 66–83]; Sp 91 [95% CI: 77–98]) but had a higher Sn and Sp. The sPLA2-IIA was also found superior to N%, PCT, and lactate. This finding suggested sPLA2-IIA was recommended biomarkers for BI detection in LMIC.Toh Leong TanChristabel Wan-li KangKai Shen OoiSwee Thian TanNurul Saadah AhmadDian Nasriana NasuruddinAzlin IthninKhaizurin Tajul ArifinLee Yook HengNurul Izzaty HassanKok Beng GanHui-min NeohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toh Leong Tan Christabel Wan-li Kang Kai Shen Ooi Swee Thian Tan Nurul Saadah Ahmad Dian Nasriana Nasuruddin Azlin Ithnin Khaizurin Tajul Arifin Lee Yook Heng Nurul Izzaty Hassan Kok Beng Gan Hui-min Neoh Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection
description	Abstract Early bacterial infection (BI) identification in resource-limiting Emergency Departments (ED) is challenging, especially in low- and middle-income counties (LMIC). Misdiagnosis predisposes to antibiotic overuse and propagates antimicrobial resistance. This study evaluates new emerging biomarkers, secretory phospholipase A2 group IIA (sPLA2-IIA) and compares with other biomarkers on their performance characteristic of BI detection in Malaysia, an LMIC. A prospective cohort study was conducted involving 151 consecutive patients admitted to the ED. A single measurement was taken upon patient arrival in ED and was analysed for serum levels of sPLA2-IIA, high-sensitive C-reactive protein (CRP), procalcitonin (PCT), neutrophil percentage (N%), and lactate. All biomarkers’ performance was compared for the outcomes using area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity. The performance of sPLA2-IIA (AUROC 0.93 [95% CI: 0.89–0.97]; Sn 80% [95% CI: 72–87]; Sp 94% [95% CI: 81–89]) was the highest among all. It was comparable with high-sensitive CRP (AUROC 0.93 [95% CI: 0.88–0.97]; Sn 75% [95% CI: 66–83]; Sp 91 [95% CI: 77–98]) but had a higher Sn and Sp. The sPLA2-IIA was also found superior to N%, PCT, and lactate. This finding suggested sPLA2-IIA was recommended biomarkers for BI detection in LMIC.
format	article
author	Toh Leong Tan Christabel Wan-li Kang Kai Shen Ooi Swee Thian Tan Nurul Saadah Ahmad Dian Nasriana Nasuruddin Azlin Ithnin Khaizurin Tajul Arifin Lee Yook Heng Nurul Izzaty Hassan Kok Beng Gan Hui-min Neoh
author_facet	Toh Leong Tan Christabel Wan-li Kang Kai Shen Ooi Swee Thian Tan Nurul Saadah Ahmad Dian Nasriana Nasuruddin Azlin Ithnin Khaizurin Tajul Arifin Lee Yook Heng Nurul Izzaty Hassan Kok Beng Gan Hui-min Neoh
author_sort	Toh Leong Tan
title	Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection
title_short	Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection
title_full	Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection
title_fullStr	Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection
title_full_unstemmed	Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection
title_sort	comparison of spla2iia performance with high-sensitive crp neutrophil percentage pct and lactate to identify bacterial infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b25a115748d54f5a84a791ac14fc1a4e
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Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage PCT and lactate to identify bacterial infection

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