Nanoparticles of barium induce apoptosis in human phagocytes

Luana Mores, Eduardo Luzia França, Núbia Andrade Silva, Eliane Aparecida Suchara, Adenilda Cristina Honorio-França Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, Mato Grosso, Brazil Purpose: Nutrients and...

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Autores principales:	Mores L, França EL, Silva NA, Suchara EA, Honorio-França AC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b25a8034d9f247afafa5228cd0729959
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spelling	oai:doaj.org-article:b25a8034d9f247afafa5228cd07299592021-12-02T02:10:30ZNanoparticles of barium induce apoptosis in human phagocytes1178-2013https://doaj.org/article/b25a8034d9f247afafa5228cd07299592015-09-01T00:00:00Zhttps://www.dovepress.com/nanoparticles-of-barium-induce-apoptosis-in-human-phagocytes-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Luana Mores, Eduardo Luzia França, Núbia Andrade Silva, Eliane Aparecida Suchara, Adenilda Cristina Honorio-França Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, Mato Grosso, Brazil Purpose: Nutrients and immunological factors of breast milk are essential for newborn growth and the development of their immune system, but this secretion can contain organic and inorganic toxins such as barium. Colostrum contamination with barium is an important issue to investigate because this naturally occurring element is also associated with human activity and industrial pollution. The study evaluated the administration of barium nanoparticles to colostrum, assessing the viability and functional activity of colostral mononuclear phagocytes. Methods: Colostrum was collected from 24 clinically healthy women (aged 18–35 years). Cell viability, superoxide release, intracellular Ca2+ release, and phagocyte apoptosis were analyzed in the samples. Results: Treatment with barium lowered mononuclear phagocyte viability, increased superoxide release, and reduced intracellular calcium release. In addition, barium increased cell death by apoptosis. Conclusion: These data suggest that nanoparticles of barium in colostrum are toxic to cells, showing the importance of avoiding exposure to this element. Keywords: barium chloride, colostrum, immune cells, intracellular Ca2+, immunotoxicologyMores LFrança ELSilva NASuchara EAHonorio-França ACDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 6021-6026 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mores L França EL Silva NA Suchara EA Honorio-França AC Nanoparticles of barium induce apoptosis in human phagocytes
description	Luana Mores, Eduardo Luzia França, Núbia Andrade Silva, Eliane Aparecida Suchara, Adenilda Cristina Honorio-França Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, Mato Grosso, Brazil Purpose: Nutrients and immunological factors of breast milk are essential for newborn growth and the development of their immune system, but this secretion can contain organic and inorganic toxins such as barium. Colostrum contamination with barium is an important issue to investigate because this naturally occurring element is also associated with human activity and industrial pollution. The study evaluated the administration of barium nanoparticles to colostrum, assessing the viability and functional activity of colostral mononuclear phagocytes. Methods: Colostrum was collected from 24 clinically healthy women (aged 18–35 years). Cell viability, superoxide release, intracellular Ca2+ release, and phagocyte apoptosis were analyzed in the samples. Results: Treatment with barium lowered mononuclear phagocyte viability, increased superoxide release, and reduced intracellular calcium release. In addition, barium increased cell death by apoptosis. Conclusion: These data suggest that nanoparticles of barium in colostrum are toxic to cells, showing the importance of avoiding exposure to this element. Keywords: barium chloride, colostrum, immune cells, intracellular Ca2+, immunotoxicology
format	article
author	Mores L França EL Silva NA Suchara EA Honorio-França AC
author_facet	Mores L França EL Silva NA Suchara EA Honorio-França AC
author_sort	Mores L
title	Nanoparticles of barium induce apoptosis in human phagocytes
title_short	Nanoparticles of barium induce apoptosis in human phagocytes
title_full	Nanoparticles of barium induce apoptosis in human phagocytes
title_fullStr	Nanoparticles of barium induce apoptosis in human phagocytes
title_full_unstemmed	Nanoparticles of barium induce apoptosis in human phagocytes
title_sort	nanoparticles of barium induce apoptosis in human phagocytes
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/b25a8034d9f247afafa5228cd0729959
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Nanoparticles of barium induce apoptosis in human phagocytes

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