Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome

Background. The study was aimed to determine the correlation between the blood concentration of vitamin D and factors that influence the function of the endothelium and the hemodynamic of gonads in women with polycystic ovary syndrome (PCOS). Material and methods. Sixty women aged from 18 to 26 year...

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Autores principales:	T.L. Arkhypkina, V.A. Bondarenko, L.P. Lyubimovа, I.O. Bielkina, N.F. Velichko
Formato:	article
Lenguaje:	EN RU UK
Publicado:	Publishing House Zaslavsky 2021
Materias:	polycystic ovary syndrome, vitamin d, nitric oxide, arginine, c-reactive protein, interleukin-6, homocysteine Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/b25c85fb8d304b00ac440a44f334b6a4
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spelling	oai:doaj.org-article:b25c85fb8d304b00ac440a44f334b6a42021-11-22T11:26:20ZVitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome2224-07212307-142710.22141/2224-0721.17.6.2021.243206https://doaj.org/article/b25c85fb8d304b00ac440a44f334b6a42021-10-01T00:00:00Zhttp://iej.zaslavsky.com.ua/article/view/243206https://doaj.org/toc/2224-0721https://doaj.org/toc/2307-1427Background. The study was aimed to determine the correlation between the blood concentration of vitamin D and factors that influence the function of the endothelium and the hemodynamic of gonads in women with polycystic ovary syndrome (PCOS). Material and methods. Sixty women aged from 18 to 26 years were examined: 30 women with a diagnosis of PCOS and 30 healthy women. The blood serum concentration of vitamin D, C-reactive protein (CRP), interleukin-6 (IL-6), homocysteine (Hcy), nitrites/nitrates (NOx), and arginine were investigated. Maximum systolic velocity (Vmax), resistance index (RI), and pulsatility index (PI) were measured with Doppler ultrasound. Cholecalciferol was used in a dose of 4000 IU per day for 12 weeks for the correction of deficiency of vitamin D. Results. The patients with PCOS were found to have a lower (Р < 0.001) average vitamin D than healthy women. The reduction of vitamin D concentration was combined with an increase (P < 0.001) in the average concentration of NOx and a decrease in arginine. It was found a positive association between vitamin D and arginine (r = 0.391; P < 0.05), between NOx and CRP (r = 0.432; P < 0.02), IL-6 (r = 0.476; P < 0.01), Vmax (r = 0.383; P < 0.05), RI (r = 0.369; P < 0.05), PI (r = 0.380; P < 0.05) and reverse correlation with arginine (r = –0.375; P < 0.05). It was not found an association between NOx and vitamin D (r = 0.207; P > 0.05), Hcy (r = 0.176; P > 0.05); between vitamin D and Vmax (r = 0.231; P > 0.05), RI (r = 0.201; P > 0.05), PI (r = 0.181; P > 0.05). The therapy of cholecalciferol level was accompanied by an increase (P < 0.001) in concentrations of vitamin D, arginine (P < 0.05) and a decrease in NOx (P < 0.02), IL-6 (P < 0.05), SRP (P < 0.001), Hcy (P < 0.001), Vmax (P < 0.001), RI (P < 0.001), PI (P < 0.01), quantity of antral follicles (P < 0.001), and the growth of follicles (P < 0.001). However, none of the studied indicators reached the indicators in healthy women. Conclusions. The deficiency of vitamin D is associated with increased markers of chronic inflammation, homocysteine, nitrate/nitrites, reduced concentration of arginine that provokes the development of endothelium dysfunction and, therefore, the hemodynamics disorders and folliculogenesis in the ovary.T.L. ArkhypkinaV.A. BondarenkoL.P. LyubimovаI.O. BielkinaN.F. VelichkoPublishing House Zaslavskyarticlepolycystic ovary syndrome, vitamin d, nitric oxide, arginine, c-reactive protein, interleukin-6, homocysteineDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUUKMìžnarodnij Endokrinologìčnij Žurnal, Vol 17, Iss 6, Pp 459-464 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	polycystic ovary syndrome, vitamin d, nitric oxide, arginine, c-reactive protein, interleukin-6, homocysteine Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	polycystic ovary syndrome, vitamin d, nitric oxide, arginine, c-reactive protein, interleukin-6, homocysteine Diseases of the endocrine glands. Clinical endocrinology RC648-665 T.L. Arkhypkina V.A. Bondarenko L.P. Lyubimovа I.O. Bielkina N.F. Velichko Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome
description	Background. The study was aimed to determine the correlation between the blood concentration of vitamin D and factors that influence the function of the endothelium and the hemodynamic of gonads in women with polycystic ovary syndrome (PCOS). Material and methods. Sixty women aged from 18 to 26 years were examined: 30 women with a diagnosis of PCOS and 30 healthy women. The blood serum concentration of vitamin D, C-reactive protein (CRP), interleukin-6 (IL-6), homocysteine (Hcy), nitrites/nitrates (NOx), and arginine were investigated. Maximum systolic velocity (Vmax), resistance index (RI), and pulsatility index (PI) were measured with Doppler ultrasound. Cholecalciferol was used in a dose of 4000 IU per day for 12 weeks for the correction of deficiency of vitamin D. Results. The patients with PCOS were found to have a lower (Р < 0.001) average vitamin D than healthy women. The reduction of vitamin D concentration was combined with an increase (P < 0.001) in the average concentration of NOx and a decrease in arginine. It was found a positive association between vitamin D and arginine (r = 0.391; P < 0.05), between NOx and CRP (r = 0.432; P < 0.02), IL-6 (r = 0.476; P < 0.01), Vmax (r = 0.383; P < 0.05), RI (r = 0.369; P < 0.05), PI (r = 0.380; P < 0.05) and reverse correlation with arginine (r = –0.375; P < 0.05). It was not found an association between NOx and vitamin D (r = 0.207; P > 0.05), Hcy (r = 0.176; P > 0.05); between vitamin D and Vmax (r = 0.231; P > 0.05), RI (r = 0.201; P > 0.05), PI (r = 0.181; P > 0.05). The therapy of cholecalciferol level was accompanied by an increase (P < 0.001) in concentrations of vitamin D, arginine (P < 0.05) and a decrease in NOx (P < 0.02), IL-6 (P < 0.05), SRP (P < 0.001), Hcy (P < 0.001), Vmax (P < 0.001), RI (P < 0.001), PI (P < 0.01), quantity of antral follicles (P < 0.001), and the growth of follicles (P < 0.001). However, none of the studied indicators reached the indicators in healthy women. Conclusions. The deficiency of vitamin D is associated with increased markers of chronic inflammation, homocysteine, nitrate/nitrites, reduced concentration of arginine that provokes the development of endothelium dysfunction and, therefore, the hemodynamics disorders and folliculogenesis in the ovary.
format	article
author	T.L. Arkhypkina V.A. Bondarenko L.P. Lyubimovа I.O. Bielkina N.F. Velichko
author_facet	T.L. Arkhypkina V.A. Bondarenko L.P. Lyubimovа I.O. Bielkina N.F. Velichko
author_sort	T.L. Arkhypkina
title	Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome
title_short	Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome
title_full	Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome
title_fullStr	Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome
title_full_unstemmed	Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome
title_sort	vitamin d role in endothelial dysfunction development in patients with polycystic ovarian syndrome
publisher	Publishing House Zaslavsky
publishDate	2021
url	https://doaj.org/article/b25c85fb8d304b00ac440a44f334b6a4
work_keys_str_mv	AT tlarkhypkina vitamindroleinendothelialdysfunctiondevelopmentinpatientswithpolycysticovariansyndrome AT vabondarenko vitamindroleinendothelialdysfunctiondevelopmentinpatientswithpolycysticovariansyndrome AT lplyubimova vitamindroleinendothelialdysfunctiondevelopmentinpatientswithpolycysticovariansyndrome AT iobielkina vitamindroleinendothelialdysfunctiondevelopmentinpatientswithpolycysticovariansyndrome AT nfvelichko vitamindroleinendothelialdysfunctiondevelopmentinpatientswithpolycysticovariansyndrome
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Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome

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