Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease

Background: Severe asthma with persistent airflow limitation (SA-PAL) and chronic obstructive pulmonary disease (COPD) are characterised by irreversible airflow limitation and the remodelling of the airways. The phenotypes of the diseases overlap and may cause diagnostic and therapeutic concerns. Me...

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Autores principales:	Andrzej Obojski, Mateusz Patyk, Urszula Zaleska-Dorobisz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	asthma chronic obstructive pulmonary disease airway remodelling emphysema quantitative computed tomography Medicine R
Acceso en línea:	https://doaj.org/article/b25ebfab6f4a4669a1656047e70b9cf2
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spelling	oai:doaj.org-article:b25ebfab6f4a4669a1656047e70b9cf22021-11-11T17:40:50ZSimilarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease10.3390/jcm102150582077-0383https://doaj.org/article/b25ebfab6f4a4669a1656047e70b9cf22021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5058https://doaj.org/toc/2077-0383Background: Severe asthma with persistent airflow limitation (SA-PAL) and chronic obstructive pulmonary disease (COPD) are characterised by irreversible airflow limitation and the remodelling of the airways. The phenotypes of the diseases overlap and may cause diagnostic and therapeutic concerns. Methods: There were 10 patients with SA-PAL, 11 patients with COPD, and 10 healthy volunteers (HV) enrolled in this study. The patients were examined with a 128-multislice scanner at full inspiration. Measurements were taken from the third to ninth bronchial generations. Results: The thickness of the bronchial wall was greater in the SA-PAL than in the COPD group for most bronchial generations (<i>p</i> < 0.05). The mean lung density was the lowest in the SA-PAL group (−846 HU), followed by the COPD group (−836 HU), with no statistical difference between these two groups. The low-attenuation volume percentage (LAV% < −950 HU) was significantly higher in the SA-PAL group (15.8%) and COPD group (10.4%) compared with the HV group (7%) (<i>p</i> = 0.03). Conclusion: Severe asthma with persistent airflow limitation and COPD become similar with time within the functional and morphological dimensions. Emphysema qualities are present in COPD and in SA-PAL patients.Andrzej ObojskiMateusz PatykUrszula Zaleska-DorobiszMDPI AGarticleasthmachronic obstructive pulmonary diseaseairway remodellingemphysemaquantitative computed tomographyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5058, p 5058 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asthma chronic obstructive pulmonary disease airway remodelling emphysema quantitative computed tomography Medicine R
spellingShingle	asthma chronic obstructive pulmonary disease airway remodelling emphysema quantitative computed tomography Medicine R Andrzej Obojski Mateusz Patyk Urszula Zaleska-Dorobisz Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease
description	Background: Severe asthma with persistent airflow limitation (SA-PAL) and chronic obstructive pulmonary disease (COPD) are characterised by irreversible airflow limitation and the remodelling of the airways. The phenotypes of the diseases overlap and may cause diagnostic and therapeutic concerns. Methods: There were 10 patients with SA-PAL, 11 patients with COPD, and 10 healthy volunteers (HV) enrolled in this study. The patients were examined with a 128-multislice scanner at full inspiration. Measurements were taken from the third to ninth bronchial generations. Results: The thickness of the bronchial wall was greater in the SA-PAL than in the COPD group for most bronchial generations (<i>p</i> < 0.05). The mean lung density was the lowest in the SA-PAL group (−846 HU), followed by the COPD group (−836 HU), with no statistical difference between these two groups. The low-attenuation volume percentage (LAV% < −950 HU) was significantly higher in the SA-PAL group (15.8%) and COPD group (10.4%) compared with the HV group (7%) (<i>p</i> = 0.03). Conclusion: Severe asthma with persistent airflow limitation and COPD become similar with time within the functional and morphological dimensions. Emphysema qualities are present in COPD and in SA-PAL patients.
format	article
author	Andrzej Obojski Mateusz Patyk Urszula Zaleska-Dorobisz
author_facet	Andrzej Obojski Mateusz Patyk Urszula Zaleska-Dorobisz
author_sort	Andrzej Obojski
title	Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease
title_short	Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease
title_full	Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease
title_fullStr	Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease
title_sort	similarities in quantitative computed tomography imaging of the lung in severe asthma with persistent airflow limitation and chronic obstructive pulmonary disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b25ebfab6f4a4669a1656047e70b9cf2
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Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease

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