Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy

Cancer is one of the leading causes of death in the world. A cancer-targeted multifunctional probe labeled with the radionuclide has been developed to provide multi-modalities for NIR fluorescence and nuclear imaging (PET, SPECT), for photothermal therapy (PTT), and targeted radionuclide therapy of...

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Autores principales:	Cheng-Liang Peng, Ying-Hsia Shih, Ping-Fang Chiang, Chun-Tang Chen, Ming-Cheng Chang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multi-modality cyanine dye near-infrared fluorescence imaging nuclear imaging photothermal therapy targeted radionuclide therapy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b2655319a20f405a9404407765cc919f
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spelling	oai:doaj.org-article:b2655319a20f405a9404407765cc919f2021-11-25T17:54:23ZMultifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy10.3390/ijms2222122141422-00671661-6596https://doaj.org/article/b2655319a20f405a9404407765cc919f2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12214https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cancer is one of the leading causes of death in the world. A cancer-targeted multifunctional probe labeled with the radionuclide has been developed to provide multi-modalities for NIR fluorescence and nuclear imaging (PET, SPECT), for photothermal therapy (PTT), and targeted radionuclide therapy of cancer. In this study, synthesis, characterization, in vitro, and in vivo biological evaluation of the cyanine-based probe (DOTA-NIR790) were demonstrated. The use of cyanine dyes for the selective accumulation of cancer cells were used to achieve the characteristics of tumor markers. Therefore, all kinds of organ tumors can be targeted for diagnosis and treatment. The DOTA-NIR790 labeled with lutetium-111 could detect original or metastatic tumors by using SPECT imaging and quantify tumor accumulation. The β-emission of <sup>177</sup>Lu-DOTA-NIR790 can be used for targeted radionuclide therapy of tumors. The DOTA-NIR790 enabled imaging by NIR fluorescence and by nuclear imaging (SPECT) to monitor in real-time the tumor accumulation and the situation of cancer therapy, and to guide the surgery or the photothermal therapy of the tumor. The radionuclide-labeled heptamethine cyanine based probe (DOTA-NIR790) offers multifunctional modalities for imaging and therapies of cancer.Cheng-Liang PengYing-Hsia ShihPing-Fang ChiangChun-Tang ChenMing-Cheng ChangMDPI AGarticlemulti-modalitycyanine dyenear-infrared fluorescence imagingnuclear imagingphotothermal therapytargeted radionuclide therapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12214, p 12214 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multi-modality cyanine dye near-infrared fluorescence imaging nuclear imaging photothermal therapy targeted radionuclide therapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	multi-modality cyanine dye near-infrared fluorescence imaging nuclear imaging photothermal therapy targeted radionuclide therapy Biology (General) QH301-705.5 Chemistry QD1-999 Cheng-Liang Peng Ying-Hsia Shih Ping-Fang Chiang Chun-Tang Chen Ming-Cheng Chang Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy
description	Cancer is one of the leading causes of death in the world. A cancer-targeted multifunctional probe labeled with the radionuclide has been developed to provide multi-modalities for NIR fluorescence and nuclear imaging (PET, SPECT), for photothermal therapy (PTT), and targeted radionuclide therapy of cancer. In this study, synthesis, characterization, in vitro, and in vivo biological evaluation of the cyanine-based probe (DOTA-NIR790) were demonstrated. The use of cyanine dyes for the selective accumulation of cancer cells were used to achieve the characteristics of tumor markers. Therefore, all kinds of organ tumors can be targeted for diagnosis and treatment. The DOTA-NIR790 labeled with lutetium-111 could detect original or metastatic tumors by using SPECT imaging and quantify tumor accumulation. The β-emission of <sup>177</sup>Lu-DOTA-NIR790 can be used for targeted radionuclide therapy of tumors. The DOTA-NIR790 enabled imaging by NIR fluorescence and by nuclear imaging (SPECT) to monitor in real-time the tumor accumulation and the situation of cancer therapy, and to guide the surgery or the photothermal therapy of the tumor. The radionuclide-labeled heptamethine cyanine based probe (DOTA-NIR790) offers multifunctional modalities for imaging and therapies of cancer.
format	article
author	Cheng-Liang Peng Ying-Hsia Shih Ping-Fang Chiang Chun-Tang Chen Ming-Cheng Chang
author_facet	Cheng-Liang Peng Ying-Hsia Shih Ping-Fang Chiang Chun-Tang Chen Ming-Cheng Chang
author_sort	Cheng-Liang Peng
title	Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy
title_short	Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy
title_full	Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy
title_fullStr	Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy
title_full_unstemmed	Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy
title_sort	multifunctional cyanine-based theranostic probe for cancer imaging and therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b2655319a20f405a9404407765cc919f
work_keys_str_mv	AT chengliangpeng multifunctionalcyaninebasedtheranosticprobeforcancerimagingandtherapy AT yinghsiashih multifunctionalcyaninebasedtheranosticprobeforcancerimagingandtherapy AT pingfangchiang multifunctionalcyaninebasedtheranosticprobeforcancerimagingandtherapy AT chuntangchen multifunctionalcyaninebasedtheranosticprobeforcancerimagingandtherapy AT mingchengchang multifunctionalcyaninebasedtheranosticprobeforcancerimagingandtherapy
_version_	1718411881270476800

Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy

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