Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine

Liu et al. describe the antibiotic adjuvant effect of the FDA approved drug, benzydamine, for the treatment of infections caused by multidrug-resistant bacteria. Mechanistically, benzydamine dissipates membrane potential in both Gram-positive and Gram-negative bacteria, upregulates the transmembrane...

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Autores principales:	Yuan Liu, Ziwen Tong, Jingru Shi, Yuqian Jia, Tian Deng, Zhiqiang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b267cd9c901347399769c556a2740cfb
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spelling	oai:doaj.org-article:b267cd9c901347399769c556a2740cfb2021-11-28T12:10:09ZReversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine10.1038/s42003-021-02854-z2399-3642https://doaj.org/article/b267cd9c901347399769c556a2740cfb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02854-zhttps://doaj.org/toc/2399-3642Liu et al. describe the antibiotic adjuvant effect of the FDA approved drug, benzydamine, for the treatment of infections caused by multidrug-resistant bacteria. Mechanistically, benzydamine dissipates membrane potential in both Gram-positive and Gram-negative bacteria, upregulates the transmembrane proton gradient and promotes the uptake of tetracyclines, accounting for its bactericidal activity.Yuan LiuZiwen TongJingru ShiYuqian JiaTian DengZhiqiang WangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yuan Liu Ziwen Tong Jingru Shi Yuqian Jia Tian Deng Zhiqiang Wang Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
description	Liu et al. describe the antibiotic adjuvant effect of the FDA approved drug, benzydamine, for the treatment of infections caused by multidrug-resistant bacteria. Mechanistically, benzydamine dissipates membrane potential in both Gram-positive and Gram-negative bacteria, upregulates the transmembrane proton gradient and promotes the uptake of tetracyclines, accounting for its bactericidal activity.
format	article
author	Yuan Liu Ziwen Tong Jingru Shi Yuqian Jia Tian Deng Zhiqiang Wang
author_facet	Yuan Liu Ziwen Tong Jingru Shi Yuqian Jia Tian Deng Zhiqiang Wang
author_sort	Yuan Liu
title	Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
title_short	Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
title_full	Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
title_fullStr	Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
title_full_unstemmed	Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
title_sort	reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b267cd9c901347399769c556a2740cfb
work_keys_str_mv	AT yuanliu reversionofantibioticresistanceinmultidrugresistantpathogensusingnonantibioticpharmaceuticalbenzydamine AT ziwentong reversionofantibioticresistanceinmultidrugresistantpathogensusingnonantibioticpharmaceuticalbenzydamine AT jingrushi reversionofantibioticresistanceinmultidrugresistantpathogensusingnonantibioticpharmaceuticalbenzydamine AT yuqianjia reversionofantibioticresistanceinmultidrugresistantpathogensusingnonantibioticpharmaceuticalbenzydamine AT tiandeng reversionofantibioticresistanceinmultidrugresistantpathogensusingnonantibioticpharmaceuticalbenzydamine AT zhiqiangwang reversionofantibioticresistanceinmultidrugresistantpathogensusingnonantibioticpharmaceuticalbenzydamine
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Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine

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