Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

Oral carcinoma represents one of the most common malignancies worldwide. Oral squamous cell carcinomas (OSCCs) account over 90% of all oral malignant tumors and are characterized by high mortality in the advanced stages. Early diagnosis is often a challenge for its ambiguous appearance in early stag...

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Autores principales:	Lorenzo Lo Muzio, Andrea Ballini, Stefania Cantore, Lucrezia Bottalico, Ioannis Alexandros Charitos, Mariateresa Ambrosino, Riccardo Nocini, Annarita Malcangi, Mario Dioguardi, Angela Pia Cazzolla, Edoardo Brauner, Luigi Santacroce, Michele Di Cosola
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/b2680ad6bdf34cbf898d08958c2c2607
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spelling	oai:doaj.org-article:b2680ad6bdf34cbf898d08958c2c26072021-11-15T01:20:15ZOverview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients2314-614110.1155/2021/7312611https://doaj.org/article/b2680ad6bdf34cbf898d08958c2c26072021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7312611https://doaj.org/toc/2314-6141Oral carcinoma represents one of the most common malignancies worldwide. Oral squamous cell carcinomas (OSCCs) account over 90% of all oral malignant tumors and are characterized by high mortality in the advanced stages. Early diagnosis is often a challenge for its ambiguous appearance in early stages. Mucosal infection by the human papillomavirus (HPV) is responsible for a growing number of malignancies, particularly cervical cancer and oropharyngeal carcinomas. In addition, Candida albicans (C. albicans), which is the principal fungi involved in the oral cancer development, may induce carcinogenesis through several mechanisms, mainly promoting inflammation. Medical knowledge and research on adolescent/pediatric patients’ management and prevention are in continuous evolution. Besides, microbiota can play an important role in maintaining oral health and therefore all human health. The aim of this review is to evaluate epidemiological and pathophysiological characteristics of the several biochemical pathways involved during HPV and C. albicans infections in pediatric dentistry.Lorenzo Lo MuzioAndrea BalliniStefania CantoreLucrezia BottalicoIoannis Alexandros CharitosMariateresa AmbrosinoRiccardo NociniAnnarita MalcangiMario DioguardiAngela Pia CazzollaEdoardo BraunerLuigi SantacroceMichele Di CosolaHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Lorenzo Lo Muzio Andrea Ballini Stefania Cantore Lucrezia Bottalico Ioannis Alexandros Charitos Mariateresa Ambrosino Riccardo Nocini Annarita Malcangi Mario Dioguardi Angela Pia Cazzolla Edoardo Brauner Luigi Santacroce Michele Di Cosola Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients
description	Oral carcinoma represents one of the most common malignancies worldwide. Oral squamous cell carcinomas (OSCCs) account over 90% of all oral malignant tumors and are characterized by high mortality in the advanced stages. Early diagnosis is often a challenge for its ambiguous appearance in early stages. Mucosal infection by the human papillomavirus (HPV) is responsible for a growing number of malignancies, particularly cervical cancer and oropharyngeal carcinomas. In addition, Candida albicans (C. albicans), which is the principal fungi involved in the oral cancer development, may induce carcinogenesis through several mechanisms, mainly promoting inflammation. Medical knowledge and research on adolescent/pediatric patients’ management and prevention are in continuous evolution. Besides, microbiota can play an important role in maintaining oral health and therefore all human health. The aim of this review is to evaluate epidemiological and pathophysiological characteristics of the several biochemical pathways involved during HPV and C. albicans infections in pediatric dentistry.
format	article
author	Lorenzo Lo Muzio Andrea Ballini Stefania Cantore Lucrezia Bottalico Ioannis Alexandros Charitos Mariateresa Ambrosino Riccardo Nocini Annarita Malcangi Mario Dioguardi Angela Pia Cazzolla Edoardo Brauner Luigi Santacroce Michele Di Cosola
author_facet	Lorenzo Lo Muzio Andrea Ballini Stefania Cantore Lucrezia Bottalico Ioannis Alexandros Charitos Mariateresa Ambrosino Riccardo Nocini Annarita Malcangi Mario Dioguardi Angela Pia Cazzolla Edoardo Brauner Luigi Santacroce Michele Di Cosola
author_sort	Lorenzo Lo Muzio
title	Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients
title_short	Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients
title_full	Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients
title_fullStr	Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients
title_full_unstemmed	Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients
title_sort	overview of candida albicans and human papillomavirus (hpv) infection agents and their biomolecular mechanisms in promoting oral cancer in pediatric patients
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/b2680ad6bdf34cbf898d08958c2c2607
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Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

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