The Nontypeable <named-content content-type="genus-species">Haemophilus influenzae</named-content> Major Adhesin Hia Is a Dual-Function Lectin That Binds to Human-Specific Respiratory Tract Sialic Acid Glycan Receptors

The Nontypeable <named-content content-type="genus-species">Haemophilus influenzae</named-content> Major Adhesin Hia Is a Dual-Function Lectin That Binds to Human-Specific Respiratory Tract Sialic Acid Glycan Receptors

ABSTRACT NTHi is a human-adapted pathogen that colonizes the human respiratory tract. Strains of NTHi express multiple adhesins; however, there is a unique, mutually exclusive relationship between the major adhesins Hia and HMW1 and HMW2 (HMW1/2). Approximately 25% of NTHi strains express Hia, a pha...

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Autores principales: John M. Atack, Christopher J. Day, Jessica Poole, Kenneth L. Brockman, Jamie R. L. Timms, Linda E. Winter, Thomas Haselhorst, Lauren O. Bakaletz, Stephen J. Barenkamp, Michael P. Jennings
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
COPD
NTHi
adhesin
autotransporter proteins
bacterial pathogen
glycan
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/b2682d6d2df04df69b1bd523da687501
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