Cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates

Cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates

Dana Kamaradova,1,2 Miroslav Hajda,1,2 Jan Prasko,1,2 Jiri Taborsky,1,2 Ales Grambal,1,2 Klara Latalova,1,2 Marie Ociskova,1,2 Martin Brunovsky,3 Petr Hlustik4,5 1Department of Psychiatry, University Hospital Olomouc, 2Department of Psychiatry, Palacky University Olomouc, Olomouc, 3National Institu...

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Autores principales: Kamaradova D, Hajda M, Prasko J, Taborsky J, Grambal A, Latalova K, Ociskova M, Brunovsky M, Hlustik P
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
Obsessive-compulsive disorder (OCD)
Electroencephalography (EEG)
Standardized low-resolution electromagnetic tomography (sLORETA)
Low-frequency sources
frontal areas
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/b2689bd165484ffa8761746ae3f02885
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spelling oai:doaj.org-article:b2689bd165484ffa8761746ae3f028852021-12-02T08:18:54ZCognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates1178-2021https://doaj.org/article/b2689bd165484ffa8761746ae3f028852016-05-01T00:00:00Zhttps://www.dovepress.com/cognitive-deficits-in-patients-with-obsessivendashcompulsive-disorder--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dana Kamaradova,1,2 Miroslav Hajda,1,2 Jan Prasko,1,2 Jiri Taborsky,1,2 Ales Grambal,1,2 Klara Latalova,1,2 Marie Ociskova,1,2 Martin Brunovsky,3 Petr Hlustik4,5 1Department of Psychiatry, University Hospital Olomouc, 2Department of Psychiatry, Palacky University Olomouc, Olomouc, 3National Institute of Mental Health, Klecany, 4Department of Neurology, University Hospital Olomouc, 5Department of Neurology, Palacky University, Olomouc, Czech Republic Background: Obsessive–compulsive disorder (OCD) is associated with cognitive dysfunction. Although there are several studies focused on the neurobiology of OCD, little is known about the biological correlates of the cognitive deficit linked to this disorder. The aim of our study was to examine the association between cognitive impairment and current source density markers in patients with OCD.Methods: Resting-state eyes-closed electroencephalography (EEG) data were recorded in 20 patients with OCD and 15 healthy controls who were involved in the study. Cortical EEG sources were estimated by standardized low-resolution electromagnetic tomography in seven frequency bands: delta (1.5–6 Hz), theta (6.5–8 Hz), alpha-1 (8.5–10 Hz), alpha-2 (10.5–12 Hz), beta-1 (12.5–18 Hz), beta-2 (18.5–21 Hz), and beta-3 (21.5–30 Hz). Cognitive performance was measured by the Trail-Making Test (versions A and B), Stroop CW Test, and D2 Test.Results: Frontal delta and theta EEG sources showed significantly higher activity in the whole group of patients with OCD (N=20) than in control subjects (N=15). Subsequent analysis revealed that this excess of low-frequency activity was present only in the subgroup of eleven patients with cognitive impairment (based on the performance in the Trail-Making Test – A). The subgroup of patients with normal cognitive functions (N=9) did not differ in cortical EEG sources from healthy controls.Conclusion: The present results suggest that frontal low-frequency cortical sources of resting-state EEG rhythms can distinguish groups of cognitively impaired and cognitively intact patients with OCD. Based on our results, future studies should consider whether the present methodological approach provides clinically useful information for the revelation of cognitive impairment in patients with OCD. Keywords: obsessive–compulsive disorder, electroencephalography, standardized low-resolution electromagnetic tomography, low-frequency sources, frontal areasKamaradova DHajda MPrasko JTaborsky JGrambal ALatalova KOciskova MBrunovsky MHlustik PDove Medical PressarticleObsessive-compulsive disorder (OCD)Electroencephalography (EEG)Standardized low-resolution electromagnetic tomography (sLORETA)Low-frequency sourcesfrontal areasNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1119-1125 (2016)
institution DOAJ
collection DOAJ
language EN
topic Obsessive-compulsive disorder (OCD)
Electroencephalography (EEG)
Standardized low-resolution electromagnetic tomography (sLORETA)
Low-frequency sources
frontal areas
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Obsessive-compulsive disorder (OCD)
Electroencephalography (EEG)
Standardized low-resolution electromagnetic tomography (sLORETA)
Low-frequency sources
frontal areas
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Kamaradova D
Hajda M
Prasko J
Taborsky J
Grambal A
Latalova K
Ociskova M
Brunovsky M
Hlustik P
Cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates
description Dana Kamaradova,1,2 Miroslav Hajda,1,2 Jan Prasko,1,2 Jiri Taborsky,1,2 Ales Grambal,1,2 Klara Latalova,1,2 Marie Ociskova,1,2 Martin Brunovsky,3 Petr Hlustik4,5 1Department of Psychiatry, University Hospital Olomouc, 2Department of Psychiatry, Palacky University Olomouc, Olomouc, 3National Institute of Mental Health, Klecany, 4Department of Neurology, University Hospital Olomouc, 5Department of Neurology, Palacky University, Olomouc, Czech Republic Background: Obsessive–compulsive disorder (OCD) is associated with cognitive dysfunction. Although there are several studies focused on the neurobiology of OCD, little is known about the biological correlates of the cognitive deficit linked to this disorder. The aim of our study was to examine the association between cognitive impairment and current source density markers in patients with OCD.Methods: Resting-state eyes-closed electroencephalography (EEG) data were recorded in 20 patients with OCD and 15 healthy controls who were involved in the study. Cortical EEG sources were estimated by standardized low-resolution electromagnetic tomography in seven frequency bands: delta (1.5–6 Hz), theta (6.5–8 Hz), alpha-1 (8.5–10 Hz), alpha-2 (10.5–12 Hz), beta-1 (12.5–18 Hz), beta-2 (18.5–21 Hz), and beta-3 (21.5–30 Hz). Cognitive performance was measured by the Trail-Making Test (versions A and B), Stroop CW Test, and D2 Test.Results: Frontal delta and theta EEG sources showed significantly higher activity in the whole group of patients with OCD (N=20) than in control subjects (N=15). Subsequent analysis revealed that this excess of low-frequency activity was present only in the subgroup of eleven patients with cognitive impairment (based on the performance in the Trail-Making Test – A). The subgroup of patients with normal cognitive functions (N=9) did not differ in cortical EEG sources from healthy controls.Conclusion: The present results suggest that frontal low-frequency cortical sources of resting-state EEG rhythms can distinguish groups of cognitively impaired and cognitively intact patients with OCD. Based on our results, future studies should consider whether the present methodological approach provides clinically useful information for the revelation of cognitive impairment in patients with OCD. Keywords: obsessive–compulsive disorder, electroencephalography, standardized low-resolution electromagnetic tomography, low-frequency sources, frontal areas
format article
author Kamaradova D
Hajda M
Prasko J
Taborsky J
Grambal A
Latalova K
Ociskova M
Brunovsky M
Hlustik P
author_facet Kamaradova D
Hajda M
Prasko J
Taborsky J
Grambal A
Latalova K
Ociskova M
Brunovsky M
Hlustik P
author_sort Kamaradova D
title Cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates
title_short Cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates
title_full Cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates
title_fullStr Cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates
title_full_unstemmed Cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates
title_sort cognitive deficits in patients with obsessive–compulsive disorder – electroencephalography correlates
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/b2689bd165484ffa8761746ae3f02885
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