Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes

BACKGROUND AND OBJECTIVE: Urtica is a dioecious plant, which has been introduced in Iranian traditional medicine as anti-diabetes. Since, the metabolic disorder caused by diabetes causes secondary pathophysiologic changes in multiple organs of the body, so the objective of this study was to investig...

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Autores principales:	T Rezaei Aref, B Minaii Zangii, M Latifpour
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	urtica dioica diabetes small intestine streptozotocin Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b26d394fda4d48bc8acef2fa3d2a02d1
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spelling	oai:doaj.org-article:b26d394fda4d48bc8acef2fa3d2a02d12021-11-10T08:53:11ZProtective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes1561-41072251-7170https://doaj.org/article/b26d394fda4d48bc8acef2fa3d2a02d12012-05-01T00:00:00Zhttp://jbums.org/article-1-4087-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Urtica is a dioecious plant, which has been introduced in Iranian traditional medicine as anti-diabetes. Since, the metabolic disorder caused by diabetes causes secondary pathophysiologic changes in multiple organs of the body, so the objective of this study was to investigate protective effects of Urtica Dioica extract on the small intestinal mucosa in addition to its anti diabetic effect. METHODS: In this experimental study, 14 male adult Wistar rats weighing 250-300 grams, in two groups (n=7) were used. First, the rats received an injection of streptozotocin (STZ) 50 mg/kg IV. The animals with fasting blood sugar more than 250 mg/dl were considered diabetic, one group of diabetic animals were treated with watery extract of Urtica dioica leaves (4 mg/kg daily IP injection) and other diabetic groups were considered as controls. After two months, the blood and intestinal tissue sample were taken and observed by histologist for the study of tissue parameters.FINDINGS: Blood sugar in treated group decreased from 400±52.2 mg/dl to 78.9±11.9 mg/dl (p<0.0004), whereas no change observed in diabetic group. In diabetic group, unlike the treated group necrosis and infiltration of mononuclear cells and damaged tissues were observed. Epithelium and lieberkuhn glands were destroyed, intestinal villa was shorted and atrophied, and also there were many cases of bleeding and exudates. CONCLUSION: The results of this study showed that urtica dioica has protective effect on small intestinal mucosa.T Rezaei ArefB Minaii ZangiiM LatifpourBabol University of Medical Sciencesarticleurtica dioicadiabetessmall intestinestreptozotocinMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 3, Pp 31-37 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	urtica dioica diabetes small intestine streptozotocin Medicine R Medicine (General) R5-920
spellingShingle	urtica dioica diabetes small intestine streptozotocin Medicine R Medicine (General) R5-920 T Rezaei Aref B Minaii Zangii M Latifpour Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes
description	BACKGROUND AND OBJECTIVE: Urtica is a dioecious plant, which has been introduced in Iranian traditional medicine as anti-diabetes. Since, the metabolic disorder caused by diabetes causes secondary pathophysiologic changes in multiple organs of the body, so the objective of this study was to investigate protective effects of Urtica Dioica extract on the small intestinal mucosa in addition to its anti diabetic effect. METHODS: In this experimental study, 14 male adult Wistar rats weighing 250-300 grams, in two groups (n=7) were used. First, the rats received an injection of streptozotocin (STZ) 50 mg/kg IV. The animals with fasting blood sugar more than 250 mg/dl were considered diabetic, one group of diabetic animals were treated with watery extract of Urtica dioica leaves (4 mg/kg daily IP injection) and other diabetic groups were considered as controls. After two months, the blood and intestinal tissue sample were taken and observed by histologist for the study of tissue parameters.FINDINGS: Blood sugar in treated group decreased from 400±52.2 mg/dl to 78.9±11.9 mg/dl (p<0.0004), whereas no change observed in diabetic group. In diabetic group, unlike the treated group necrosis and infiltration of mononuclear cells and damaged tissues were observed. Epithelium and lieberkuhn glands were destroyed, intestinal villa was shorted and atrophied, and also there were many cases of bleeding and exudates. CONCLUSION: The results of this study showed that urtica dioica has protective effect on small intestinal mucosa.
format	article
author	T Rezaei Aref B Minaii Zangii M Latifpour
author_facet	T Rezaei Aref B Minaii Zangii M Latifpour
author_sort	T Rezaei Aref
title	Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes
title_short	Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes
title_full	Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes
title_fullStr	Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes
title_full_unstemmed	Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes
title_sort	protective effects of urtica dioica extract on the damage of rat small intestinal mucosa caused by diabetes
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/b26d394fda4d48bc8acef2fa3d2a02d1
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Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes

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