Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients

Stefanie Hecker-Nolting,1 Thorsten Langer,2 Claudia Blattmann,1 Leo Kager,3 Stefan S Bielack1,4 1Pädiatrie 5 (Onkologie, Hämatologie, Immunologie), Zentrum für Kinder-, Jugend- und Frauenmedizin, Stuttgart Cancer Center, Klinikum Stuttgart – Olgahospital, Stuttgart, Germany; 2Pädiatrische Onkologie...

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Autores principales:	Hecker-Nolting S, Langer T, Blattmann C, Kager L, Bielack SS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	osteosarcoma child adolescent chemotherapy late effects Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b27011ce842b42a98e58b209f1f2fdd1
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spelling	oai:doaj.org-article:b27011ce842b42a98e58b209f1f2fdd12021-12-02T19:17:36ZCurrent Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients1179-1322https://doaj.org/article/b27011ce842b42a98e58b209f1f2fdd12021-12-01T00:00:00Zhttps://www.dovepress.com/current-insights-into-the-management-of-late-chemotherapy-toxicities-i-peer-reviewed-fulltext-article-CMARhttps://doaj.org/toc/1179-1322Stefanie Hecker-Nolting,1 Thorsten Langer,2 Claudia Blattmann,1 Leo Kager,3 Stefan S Bielack1,4 1Pädiatrie 5 (Onkologie, Hämatologie, Immunologie), Zentrum für Kinder-, Jugend- und Frauenmedizin, Stuttgart Cancer Center, Klinikum Stuttgart – Olgahospital, Stuttgart, Germany; 2Pädiatrische Onkologie und Hämatologie, Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany; 3St. Anna Kinderspital, Abteilung für Kinder- und Jugendheilkunde, Medizinische Universität Wien, Vienna, Austria; 4Abteilung für Pädiatrische Hämatologie und Onkologie, Klinik für Kinder- und Jugendmedizin – Pädiatrische Hämatologie und Onkologie, Münster, GermanyCorrespondence: Stefan S BielackPädiatrie 5 (Onkologie, Hämatologie, Immunologie) Zentrum für Kinder-, Jugend- und Frauenmedizin, Stuttgart Cancer Center, Klinikum Stuttgart – Olgahospital, Kriegsbergstr. 62, Stuttgart, 70174, GermanyTel +49 711 2787 3881Fax +49 711 2787-3882Email coss@klinikum-stuttgart.deAbstract: With ever increasing long-term, disease free survival rates, long-term toxicities of otherwise successful therapy have gained increasing importance. They can be grouped into potentially life-threatening, especially secondary malignancies and anthracycline cardiomyopathies, potentially disabling, particularly severe hearing loss and renal insufficiency, other, and rare events. Pathophysiology, frequency, and medical treatment approaches are discussed. Finally, fertility issues and quality of life issues are discussed, together with an outlook into the future. The challenge to cure as many patients as possible from osteosarcoma while enabling a life free of late effects will remain.Keywords: osteosarcoma, child, adolescent, chemotherapy, late effectsHecker-Nolting SLanger TBlattmann CKager LBielack SSDove Medical Pressarticleosteosarcomachildadolescentchemotherapylate effectsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Management and Research, Vol Volume 13, Pp 8989-8998 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteosarcoma child adolescent chemotherapy late effects Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	osteosarcoma child adolescent chemotherapy late effects Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hecker-Nolting S Langer T Blattmann C Kager L Bielack SS Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients
description	Stefanie Hecker-Nolting,1 Thorsten Langer,2 Claudia Blattmann,1 Leo Kager,3 Stefan S Bielack1,4 1Pädiatrie 5 (Onkologie, Hämatologie, Immunologie), Zentrum für Kinder-, Jugend- und Frauenmedizin, Stuttgart Cancer Center, Klinikum Stuttgart – Olgahospital, Stuttgart, Germany; 2Pädiatrische Onkologie und Hämatologie, Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany; 3St. Anna Kinderspital, Abteilung für Kinder- und Jugendheilkunde, Medizinische Universität Wien, Vienna, Austria; 4Abteilung für Pädiatrische Hämatologie und Onkologie, Klinik für Kinder- und Jugendmedizin – Pädiatrische Hämatologie und Onkologie, Münster, GermanyCorrespondence: Stefan S BielackPädiatrie 5 (Onkologie, Hämatologie, Immunologie) Zentrum für Kinder-, Jugend- und Frauenmedizin, Stuttgart Cancer Center, Klinikum Stuttgart – Olgahospital, Kriegsbergstr. 62, Stuttgart, 70174, GermanyTel +49 711 2787 3881Fax +49 711 2787-3882Email coss@klinikum-stuttgart.deAbstract: With ever increasing long-term, disease free survival rates, long-term toxicities of otherwise successful therapy have gained increasing importance. They can be grouped into potentially life-threatening, especially secondary malignancies and anthracycline cardiomyopathies, potentially disabling, particularly severe hearing loss and renal insufficiency, other, and rare events. Pathophysiology, frequency, and medical treatment approaches are discussed. Finally, fertility issues and quality of life issues are discussed, together with an outlook into the future. The challenge to cure as many patients as possible from osteosarcoma while enabling a life free of late effects will remain.Keywords: osteosarcoma, child, adolescent, chemotherapy, late effects
format	article
author	Hecker-Nolting S Langer T Blattmann C Kager L Bielack SS
author_facet	Hecker-Nolting S Langer T Blattmann C Kager L Bielack SS
author_sort	Hecker-Nolting S
title	Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients
title_short	Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients
title_full	Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients
title_fullStr	Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients
title_full_unstemmed	Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients
title_sort	current insights into the management of late chemotherapy toxicities in pediatric osteosarcoma patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b27011ce842b42a98e58b209f1f2fdd1
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Current Insights into the Management of Late Chemotherapy Toxicities in Pediatric Osteosarcoma Patients

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