Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice

Abstract This study investigated the immune mechanisms whereby administration of Bacteroides uniformis CECT 7771 reduces metabolic dysfunction in obesity. C57BL/6 adult male mice were fed a standard diet or a Western diet high in fat and fructose, supplemented or not with B. uniformis CECT 7771 for...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emanuel Fabersani, Kevin Portune, Isabel Campillo, Inmaculada López-Almela, Sergio Montserrat-de la Paz, Marina Romaní-Pérez, Alfonso Benítez-Páez, Yolanda Sanz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b270f8d49d534c489991d419e0898244
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b270f8d49d534c489991d419e0898244
record_format	dspace
spelling	oai:doaj.org-article:b270f8d49d534c489991d419e08982442021-12-02T15:03:05ZBacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice10.1038/s41598-021-90888-y2045-2322https://doaj.org/article/b270f8d49d534c489991d419e08982442021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90888-yhttps://doaj.org/toc/2045-2322Abstract This study investigated the immune mechanisms whereby administration of Bacteroides uniformis CECT 7771 reduces metabolic dysfunction in obesity. C57BL/6 adult male mice were fed a standard diet or a Western diet high in fat and fructose, supplemented or not with B. uniformis CECT 7771 for 14 weeks. B. uniformis CECT 7771 reduced body weight gain, plasma cholesterol, triglyceride, glucose, and leptin levels; and improved oral glucose tolerance in obese mice. Moreover, B. uniformis CECT 7771 modulated the gut microbiota and immune alterations associated with obesity, increasing Tregs and reducing B cells, total macrophages and the M1/M2 ratio in both the gut and epididymal adipose tissue (EAT) of obese mice. B. uniformis CECT 7771 also increased the concentration of the anti-inflammatory cytokine IL-10 in the gut, EAT and peripheral blood, and protective cytokines TSLP and IL-33, involved in Treg induction and type 2 innate lymphoid cells activation, in the EAT. It also restored the obesity–reduced TLR5 expression in the ileum and EAT. The findings indicate that the administration of a human intestinal bacterium with immunoregulatory properties on the intestinal mucosa helps reverse the immuno-metabolic dysfunction caused by a Western diet acting over the gut-adipose tissue axis.Emanuel FabersaniKevin PortuneIsabel CampilloInmaculada López-AlmelaSergio Montserrat-de la PazMarina Romaní-PérezAlfonso Benítez-PáezYolanda SanzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emanuel Fabersani Kevin Portune Isabel Campillo Inmaculada López-Almela Sergio Montserrat-de la Paz Marina Romaní-Pérez Alfonso Benítez-Páez Yolanda Sanz Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice
description	Abstract This study investigated the immune mechanisms whereby administration of Bacteroides uniformis CECT 7771 reduces metabolic dysfunction in obesity. C57BL/6 adult male mice were fed a standard diet or a Western diet high in fat and fructose, supplemented or not with B. uniformis CECT 7771 for 14 weeks. B. uniformis CECT 7771 reduced body weight gain, plasma cholesterol, triglyceride, glucose, and leptin levels; and improved oral glucose tolerance in obese mice. Moreover, B. uniformis CECT 7771 modulated the gut microbiota and immune alterations associated with obesity, increasing Tregs and reducing B cells, total macrophages and the M1/M2 ratio in both the gut and epididymal adipose tissue (EAT) of obese mice. B. uniformis CECT 7771 also increased the concentration of the anti-inflammatory cytokine IL-10 in the gut, EAT and peripheral blood, and protective cytokines TSLP and IL-33, involved in Treg induction and type 2 innate lymphoid cells activation, in the EAT. It also restored the obesity–reduced TLR5 expression in the ileum and EAT. The findings indicate that the administration of a human intestinal bacterium with immunoregulatory properties on the intestinal mucosa helps reverse the immuno-metabolic dysfunction caused by a Western diet acting over the gut-adipose tissue axis.
format	article
author	Emanuel Fabersani Kevin Portune Isabel Campillo Inmaculada López-Almela Sergio Montserrat-de la Paz Marina Romaní-Pérez Alfonso Benítez-Páez Yolanda Sanz
author_facet	Emanuel Fabersani Kevin Portune Isabel Campillo Inmaculada López-Almela Sergio Montserrat-de la Paz Marina Romaní-Pérez Alfonso Benítez-Páez Yolanda Sanz
author_sort	Emanuel Fabersani
title	Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice
title_short	Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice
title_full	Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice
title_fullStr	Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice
title_full_unstemmed	Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice
title_sort	bacteroides uniformis cect 7771 alleviates inflammation within the gut-adipose tissue axis involving tlr5 signaling in obese mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b270f8d49d534c489991d419e0898244
work_keys_str_mv	AT emanuelfabersani bacteroidesuniformiscect7771alleviatesinflammationwithinthegutadiposetissueaxisinvolvingtlr5signalinginobesemice AT kevinportune bacteroidesuniformiscect7771alleviatesinflammationwithinthegutadiposetissueaxisinvolvingtlr5signalinginobesemice AT isabelcampillo bacteroidesuniformiscect7771alleviatesinflammationwithinthegutadiposetissueaxisinvolvingtlr5signalinginobesemice AT inmaculadalopezalmela bacteroidesuniformiscect7771alleviatesinflammationwithinthegutadiposetissueaxisinvolvingtlr5signalinginobesemice AT sergiomontserratdelapaz bacteroidesuniformiscect7771alleviatesinflammationwithinthegutadiposetissueaxisinvolvingtlr5signalinginobesemice AT marinaromaniperez bacteroidesuniformiscect7771alleviatesinflammationwithinthegutadiposetissueaxisinvolvingtlr5signalinginobesemice AT alfonsobenitezpaez bacteroidesuniformiscect7771alleviatesinflammationwithinthegutadiposetissueaxisinvolvingtlr5signalinginobesemice AT yolandasanz bacteroidesuniformiscect7771alleviatesinflammationwithinthegutadiposetissueaxisinvolvingtlr5signalinginobesemice
_version_	1718389098036592640

Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice

Ejemplares similares