An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination.

Guardado en:
Detalles Bibliográficos
Autores principales: Liqiang Feng, Qian Wang, Chao Shan, Chenchen Yang, Ying Feng, Jia Wu, Xiaolin Liu, Yiwu Zhou, Rendi Jiang, Peiyu Hu, Xinglong Liu, Fan Zhang, Pingchao Li, Xuefeng Niu, Yichu Liu, Xuehua Zheng, Jia Luo, Jing Sun, Yingying Gu, Bo Liu, Yongcun Xu, Chufang Li, Weiqi Pan, Jincun Zhao, Changwen Ke, Xinwen Chen, Tao Xu, Nanshan Zhong, Suhua Guan, Zhiming Yuan, Ling Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/b2722cb9b68f42f095aa1611002a534b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:b2722cb9b68f42f095aa1611002a534b
record_format dspace
spelling oai:doaj.org-article:b2722cb9b68f42f095aa1611002a534b2021-12-02T15:10:55ZAn adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques10.1038/s41467-020-18077-52041-1723https://doaj.org/article/b2722cb9b68f42f095aa1611002a534b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18077-5https://doaj.org/toc/2041-1723A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination.Liqiang FengQian WangChao ShanChenchen YangYing FengJia WuXiaolin LiuYiwu ZhouRendi JiangPeiyu HuXinglong LiuFan ZhangPingchao LiXuefeng NiuYichu LiuXuehua ZhengJia LuoJing SunYingying GuBo LiuYongcun XuChufang LiWeiqi PanJincun ZhaoChangwen KeXinwen ChenTao XuNanshan ZhongSuhua GuanZhiming YuanLing ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Liqiang Feng
Qian Wang
Chao Shan
Chenchen Yang
Ying Feng
Jia Wu
Xiaolin Liu
Yiwu Zhou
Rendi Jiang
Peiyu Hu
Xinglong Liu
Fan Zhang
Pingchao Li
Xuefeng Niu
Yichu Liu
Xuehua Zheng
Jia Luo
Jing Sun
Yingying Gu
Bo Liu
Yongcun Xu
Chufang Li
Weiqi Pan
Jincun Zhao
Changwen Ke
Xinwen Chen
Tao Xu
Nanshan Zhong
Suhua Guan
Zhiming Yuan
Ling Chen
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
description A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination.
format article
author Liqiang Feng
Qian Wang
Chao Shan
Chenchen Yang
Ying Feng
Jia Wu
Xiaolin Liu
Yiwu Zhou
Rendi Jiang
Peiyu Hu
Xinglong Liu
Fan Zhang
Pingchao Li
Xuefeng Niu
Yichu Liu
Xuehua Zheng
Jia Luo
Jing Sun
Yingying Gu
Bo Liu
Yongcun Xu
Chufang Li
Weiqi Pan
Jincun Zhao
Changwen Ke
Xinwen Chen
Tao Xu
Nanshan Zhong
Suhua Guan
Zhiming Yuan
Ling Chen
author_facet Liqiang Feng
Qian Wang
Chao Shan
Chenchen Yang
Ying Feng
Jia Wu
Xiaolin Liu
Yiwu Zhou
Rendi Jiang
Peiyu Hu
Xinglong Liu
Fan Zhang
Pingchao Li
Xuefeng Niu
Yichu Liu
Xuehua Zheng
Jia Luo
Jing Sun
Yingying Gu
Bo Liu
Yongcun Xu
Chufang Li
Weiqi Pan
Jincun Zhao
Changwen Ke
Xinwen Chen
Tao Xu
Nanshan Zhong
Suhua Guan
Zhiming Yuan
Ling Chen
author_sort Liqiang Feng
title An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
title_short An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
title_full An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
title_fullStr An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
title_full_unstemmed An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
title_sort adenovirus-vectored covid-19 vaccine confers protection from sars-cov-2 challenge in rhesus macaques
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b2722cb9b68f42f095aa1611002a534b
work_keys_str_mv AT liqiangfeng anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT qianwang anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT chaoshan anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT chenchenyang anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yingfeng anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT jiawu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xiaolinliu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yiwuzhou anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT rendijiang anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT peiyuhu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xinglongliu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT fanzhang anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT pingchaoli anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xuefengniu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yichuliu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xuehuazheng anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT jialuo anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT jingsun anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yingyinggu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT boliu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yongcunxu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT chufangli anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT weiqipan anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT jincunzhao anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT changwenke anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xinwenchen anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT taoxu anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT nanshanzhong anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT suhuaguan anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT zhimingyuan anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT lingchen anadenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT liqiangfeng adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT qianwang adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT chaoshan adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT chenchenyang adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yingfeng adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT jiawu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xiaolinliu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yiwuzhou adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT rendijiang adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT peiyuhu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xinglongliu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT fanzhang adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT pingchaoli adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xuefengniu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yichuliu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xuehuazheng adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT jialuo adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT jingsun adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yingyinggu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT boliu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT yongcunxu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT chufangli adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT weiqipan adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT jincunzhao adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT changwenke adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT xinwenchen adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT taoxu adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT nanshanzhong adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT suhuaguan adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT zhimingyuan adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
AT lingchen adenovirusvectoredcovid19vaccineconfersprotectionfromsarscov2challengeinrhesusmacaques
_version_ 1718387653201625088

Ejemplares similares