Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs

Small interfering RNA (siRNA) is used to regulate gene expression for therapeutic purposes, but the design of stable and efficient siRNA delivery systems is challenging. Here, the authors develop a siRNA-encapsulated and aptamer-incorporated core/shell nanoparticle for controlled siRNA delivery, wit...

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Autores principales: Chang Xue, Shuyao Hu, Zhi-Hua Gao, Lei Wang, Meng-Xue Luo, Xin Yu, Bi-Fei Li, Zhifa Shen, Zai-Sheng Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b272be0b8b48440a9d8097f0bedde329
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spelling oai:doaj.org-article:b272be0b8b48440a9d8097f0bedde3292021-12-02T15:53:07ZProgrammably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs10.1038/s41467-021-23250-52041-1723https://doaj.org/article/b272be0b8b48440a9d8097f0bedde3292021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23250-5https://doaj.org/toc/2041-1723Small interfering RNA (siRNA) is used to regulate gene expression for therapeutic purposes, but the design of stable and efficient siRNA delivery systems is challenging. Here, the authors develop a siRNA-encapsulated and aptamer-incorporated core/shell nanoparticle for controlled siRNA delivery, with high stability, tumor-specific targeting and long circulation time.Chang XueShuyao HuZhi-Hua GaoLei WangMeng-Xue LuoXin YuBi-Fei LiZhifa ShenZai-Sheng WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chang Xue
Shuyao Hu
Zhi-Hua Gao
Lei Wang
Meng-Xue Luo
Xin Yu
Bi-Fei Li
Zhifa Shen
Zai-Sheng Wu
Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
description Small interfering RNA (siRNA) is used to regulate gene expression for therapeutic purposes, but the design of stable and efficient siRNA delivery systems is challenging. Here, the authors develop a siRNA-encapsulated and aptamer-incorporated core/shell nanoparticle for controlled siRNA delivery, with high stability, tumor-specific targeting and long circulation time.
format article
author Chang Xue
Shuyao Hu
Zhi-Hua Gao
Lei Wang
Meng-Xue Luo
Xin Yu
Bi-Fei Li
Zhifa Shen
Zai-Sheng Wu
author_facet Chang Xue
Shuyao Hu
Zhi-Hua Gao
Lei Wang
Meng-Xue Luo
Xin Yu
Bi-Fei Li
Zhifa Shen
Zai-Sheng Wu
author_sort Chang Xue
title Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_short Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_full Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_fullStr Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_full_unstemmed Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_sort programmably tiling rigidified dna brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of sirnas
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b272be0b8b48440a9d8097f0bedde329
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