Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs

Small interfering RNA (siRNA) is used to regulate gene expression for therapeutic purposes, but the design of stable and efficient siRNA delivery systems is challenging. Here, the authors develop a siRNA-encapsulated and aptamer-incorporated core/shell nanoparticle for controlled siRNA delivery, wit...

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Main Authors:	Chang Xue, Shuyao Hu, Zhi-Hua Gao, Lei Wang, Meng-Xue Luo, Xin Yu, Bi-Fei Li, Zhifa Shen, Zai-Sheng Wu
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/b272be0b8b48440a9d8097f0bedde329
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spelling	oai:doaj.org-article:b272be0b8b48440a9d8097f0bedde3292021-12-02T15:53:07ZProgrammably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs10.1038/s41467-021-23250-52041-1723https://doaj.org/article/b272be0b8b48440a9d8097f0bedde3292021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23250-5https://doaj.org/toc/2041-1723Small interfering RNA (siRNA) is used to regulate gene expression for therapeutic purposes, but the design of stable and efficient siRNA delivery systems is challenging. Here, the authors develop a siRNA-encapsulated and aptamer-incorporated core/shell nanoparticle for controlled siRNA delivery, with high stability, tumor-specific targeting and long circulation time.Chang XueShuyao HuZhi-Hua GaoLei WangMeng-Xue LuoXin YuBi-Fei LiZhifa ShenZai-Sheng WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chang Xue Shuyao Hu Zhi-Hua Gao Lei Wang Meng-Xue Luo Xin Yu Bi-Fei Li Zhifa Shen Zai-Sheng Wu Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
description	Small interfering RNA (siRNA) is used to regulate gene expression for therapeutic purposes, but the design of stable and efficient siRNA delivery systems is challenging. Here, the authors develop a siRNA-encapsulated and aptamer-incorporated core/shell nanoparticle for controlled siRNA delivery, with high stability, tumor-specific targeting and long circulation time.
format	article
author	Chang Xue Shuyao Hu Zhi-Hua Gao Lei Wang Meng-Xue Luo Xin Yu Bi-Fei Li Zhifa Shen Zai-Sheng Wu
author_facet	Chang Xue Shuyao Hu Zhi-Hua Gao Lei Wang Meng-Xue Luo Xin Yu Bi-Fei Li Zhifa Shen Zai-Sheng Wu
author_sort	Chang Xue
title	Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_short	Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_full	Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_fullStr	Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_full_unstemmed	Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs
title_sort	programmably tiling rigidified dna brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of sirnas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b272be0b8b48440a9d8097f0bedde329
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Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs

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