Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis

Treatment of tuberculosis needs to be taken for several weeks, despite good potency of drugs in vitro. Here, the authors show that mesenchymal stem cells can harbor Mycobacterium tuberculosis providing a niche for evasion of anti-bacterial drugs and cytokines.

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Autores principales:	Neharika Jain, Haroon Kalam, Lakshyaveer Singh, Vartika Sharma, Saurabh Kedia, Prasenjit Das, Vineet Ahuja, Dhiraj Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b275098bf93142e3b839d17de3f790ee
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spelling	oai:doaj.org-article:b275098bf93142e3b839d17de3f790ee2021-12-02T17:23:50ZMesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis10.1038/s41467-020-16877-32041-1723https://doaj.org/article/b275098bf93142e3b839d17de3f790ee2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16877-3https://doaj.org/toc/2041-1723Treatment of tuberculosis needs to be taken for several weeks, despite good potency of drugs in vitro. Here, the authors show that mesenchymal stem cells can harbor Mycobacterium tuberculosis providing a niche for evasion of anti-bacterial drugs and cytokines.Neharika JainHaroon KalamLakshyaveer SinghVartika SharmaSaurabh KediaPrasenjit DasVineet AhujaDhiraj KumarNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Neharika Jain Haroon Kalam Lakshyaveer Singh Vartika Sharma Saurabh Kedia Prasenjit Das Vineet Ahuja Dhiraj Kumar Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis
description	Treatment of tuberculosis needs to be taken for several weeks, despite good potency of drugs in vitro. Here, the authors show that mesenchymal stem cells can harbor Mycobacterium tuberculosis providing a niche for evasion of anti-bacterial drugs and cytokines.
format	article
author	Neharika Jain Haroon Kalam Lakshyaveer Singh Vartika Sharma Saurabh Kedia Prasenjit Das Vineet Ahuja Dhiraj Kumar
author_facet	Neharika Jain Haroon Kalam Lakshyaveer Singh Vartika Sharma Saurabh Kedia Prasenjit Das Vineet Ahuja Dhiraj Kumar
author_sort	Neharika Jain
title	Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis
title_short	Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis
title_full	Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis
title_fullStr	Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis
title_full_unstemmed	Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis
title_sort	mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b275098bf93142e3b839d17de3f790ee
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Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis

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