Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?

Background: The SARS-CoV-2 virus continues to spread rapidly across the globe afflicting many with Coronavirus Disease 2019 (COVID-19). As the infection rates rise, a growing number of SARS-CoV-2 positive individuals have been reported to complain of olfactory disturbances at an alarming rate. Postv...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sarah A. Imam, MD, Wilson P. Lao, BS, Priyanka Reddy, BS, Shaun A. Nguyen, MD, FAPCR, Rodney J. Schlosser, MD
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Olfaction Olfactory disorders UPSIT SARS-CoV-2 (COVID-19) Postviral olfactory dysfunction Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/b277b6f2cadc44b09394921565bba665
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b277b6f2cadc44b09394921565bba665
record_format	dspace
spelling	oai:doaj.org-article:b277b6f2cadc44b09394921565bba6652021-12-02T14:23:47ZIs SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?2095-881110.1016/j.wjorl.2020.05.004https://doaj.org/article/b277b6f2cadc44b09394921565bba6652020-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881120300640https://doaj.org/toc/2095-8811Background: The SARS-CoV-2 virus continues to spread rapidly across the globe afflicting many with Coronavirus Disease 2019 (COVID-19). As the infection rates rise, a growing number of SARS-CoV-2 positive individuals have been reported to complain of olfactory disturbances at an alarming rate. Postviral olfactory dysfunction (PVOD) is a well-known phenomenon that may explain the olfactory dysfunction reported by SARS-CoV-2 infected individuals. Methods: A scoping literature review was performed to identify studies that investigated the mechanisms of postviral olfactory dysfunction. Studies demonstrating pathophysiological, histological, immunochemical, and epidemiological outcomes of PVOD were included. Results: Fourteen studies were included in addition to one international news article. Three studies reported destruction of the olfactory epithelium following intranasal inoculation of various viral strains in mice. Three studies isolated pathogenic, anosmia inciting viruses (Parainfluenza virus, Human Coronavirus, Rhinovirus) through nucleic acid amplification. Eleven studies demonstrated female predilection in patients with PVOD and COVID-19 associated olfactory dysfunction, of which the majority were over 50 years old. Conclusions: PVOD and COVID-19 associated olfactory dysfunction demonstrates considerable similarities in epidemiological trends and disease sequela of other viruses to suggest identical pathophysiological mechanisms. Further studies such as intranasal inoculation and histological biopsies are needed to support our hypothesis.Sarah A. Imam, MDWilson P. Lao, BSPriyanka Reddy, BSShaun A. Nguyen, MD, FAPCRRodney J. Schlosser, MDKeAi Communications Co., Ltd.articleOlfactionOlfactory disordersUPSITSARS-CoV-2 (COVID-19)Postviral olfactory dysfunctionOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 6, Iss , Pp S26-S32 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Olfaction Olfactory disorders UPSIT SARS-CoV-2 (COVID-19) Postviral olfactory dysfunction Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Olfaction Olfactory disorders UPSIT SARS-CoV-2 (COVID-19) Postviral olfactory dysfunction Otorhinolaryngology RF1-547 Surgery RD1-811 Sarah A. Imam, MD Wilson P. Lao, BS Priyanka Reddy, BS Shaun A. Nguyen, MD, FAPCR Rodney J. Schlosser, MD Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?
description	Background: The SARS-CoV-2 virus continues to spread rapidly across the globe afflicting many with Coronavirus Disease 2019 (COVID-19). As the infection rates rise, a growing number of SARS-CoV-2 positive individuals have been reported to complain of olfactory disturbances at an alarming rate. Postviral olfactory dysfunction (PVOD) is a well-known phenomenon that may explain the olfactory dysfunction reported by SARS-CoV-2 infected individuals. Methods: A scoping literature review was performed to identify studies that investigated the mechanisms of postviral olfactory dysfunction. Studies demonstrating pathophysiological, histological, immunochemical, and epidemiological outcomes of PVOD were included. Results: Fourteen studies were included in addition to one international news article. Three studies reported destruction of the olfactory epithelium following intranasal inoculation of various viral strains in mice. Three studies isolated pathogenic, anosmia inciting viruses (Parainfluenza virus, Human Coronavirus, Rhinovirus) through nucleic acid amplification. Eleven studies demonstrated female predilection in patients with PVOD and COVID-19 associated olfactory dysfunction, of which the majority were over 50 years old. Conclusions: PVOD and COVID-19 associated olfactory dysfunction demonstrates considerable similarities in epidemiological trends and disease sequela of other viruses to suggest identical pathophysiological mechanisms. Further studies such as intranasal inoculation and histological biopsies are needed to support our hypothesis.
format	article
author	Sarah A. Imam, MD Wilson P. Lao, BS Priyanka Reddy, BS Shaun A. Nguyen, MD, FAPCR Rodney J. Schlosser, MD
author_facet	Sarah A. Imam, MD Wilson P. Lao, BS Priyanka Reddy, BS Shaun A. Nguyen, MD, FAPCR Rodney J. Schlosser, MD
author_sort	Sarah A. Imam, MD
title	Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?
title_short	Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?
title_full	Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?
title_fullStr	Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?
title_full_unstemmed	Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?
title_sort	is sars-cov-2 (covid-19) postviral olfactory dysfunction (pvod) different from other pvod?
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/b277b6f2cadc44b09394921565bba665
work_keys_str_mv	AT sarahaimammd issarscov2covid19postviralolfactorydysfunctionpvoddifferentfromotherpvod AT wilsonplaobs issarscov2covid19postviralolfactorydysfunctionpvoddifferentfromotherpvod AT priyankareddybs issarscov2covid19postviralolfactorydysfunctionpvoddifferentfromotherpvod AT shaunanguyenmdfapcr issarscov2covid19postviralolfactorydysfunctionpvoddifferentfromotherpvod AT rodneyjschlossermd issarscov2covid19postviralolfactorydysfunctionpvoddifferentfromotherpvod
_version_	1718391446100246528

Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?

Ejemplares similares