A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action o...
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Nature Portfolio
2017
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oai:doaj.org-article:b2795e546e554183a50a6e56dd7ff1b42021-12-02T15:05:14ZA miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling10.1038/s41598-017-09604-42045-2322https://doaj.org/article/b2795e546e554183a50a6e56dd7ff1b42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09604-4https://doaj.org/toc/2045-2322Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action of this FZD4-miR-SNP biomarker in a cellular platform. Our data suggest that FZD4-miR-SNP loci may significantly influence overall survival in NSCLC patients by specifically interacting with miR-204 and modulating FZD4 expression and cellular function in the Wnt-signaling-driven tumor progression. Our findings are bridging the gap between the discovery of epidemiological SNP biomarkers and their biological function and will enable us to develop novel therapeutic strategies that specifically target epigenetic markers in the oncogenic Wnt/FZD signaling pathways in NSCLC.Jing LinRoza ZandiRuping ShaoJian GuYuanqin YeJing WangYang ZhaoAlexander PertsemlidisIgnacio I. WistubaXifeng WuJack A. RothLin JiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Jing Lin Roza Zandi Ruping Shao Jian Gu Yuanqin Ye Jing Wang Yang Zhao Alexander Pertsemlidis Ignacio I. Wistuba Xifeng Wu Jack A. Roth Lin Ji A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling |
| description |
Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action of this FZD4-miR-SNP biomarker in a cellular platform. Our data suggest that FZD4-miR-SNP loci may significantly influence overall survival in NSCLC patients by specifically interacting with miR-204 and modulating FZD4 expression and cellular function in the Wnt-signaling-driven tumor progression. Our findings are bridging the gap between the discovery of epidemiological SNP biomarkers and their biological function and will enable us to develop novel therapeutic strategies that specifically target epigenetic markers in the oncogenic Wnt/FZD signaling pathways in NSCLC. |
| format |
article |
| author |
Jing Lin Roza Zandi Ruping Shao Jian Gu Yuanqin Ye Jing Wang Yang Zhao Alexander Pertsemlidis Ignacio I. Wistuba Xifeng Wu Jack A. Roth Lin Ji |
| author_facet |
Jing Lin Roza Zandi Ruping Shao Jian Gu Yuanqin Ye Jing Wang Yang Zhao Alexander Pertsemlidis Ignacio I. Wistuba Xifeng Wu Jack A. Roth Lin Ji |
| author_sort |
Jing Lin |
| title |
A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling |
| title_short |
A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling |
| title_full |
A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling |
| title_fullStr |
A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling |
| title_full_unstemmed |
A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling |
| title_sort |
mir-snp biomarker linked to an increased lung cancer survival by mirna-mediated down-regulation of fzd4 expression and wnt signaling |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/b2795e546e554183a50a6e56dd7ff1b4 |
| work_keys_str_mv |
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