Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology
Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the place...
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Nature Portfolio
2018
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oai:doaj.org-article:b27991f416df40acb0fbda1482c193c42021-12-02T17:31:58ZZika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology10.1038/s41467-017-02499-92041-1723https://doaj.org/article/b27991f416df40acb0fbda1482c193c42018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02499-9https://doaj.org/toc/2041-1723Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the placenta.Alec J. HirschVictoria H. J. RobertsPeta L. GrigsbyNicole HaeseMatthias C. SchabelXiaojie WangJamie O. LoZheng LiuChristopher D. KroenkeJessica L. SmithMeredith KelleherRebecca BroeckelCraig N. KreklywichChristopher J. ParkinsMichael DentonPatricia SmithVictor DeFilippisWilliam MesserJay A. NelsonJon D. HenneboldMarjorie GrafeLois ColginAnne LewisRebecca DucoreTonya SwansonAlfred W. LegasseMichael K. AxthelmRhonda MacAllisterAshlee V. MosesTerry K. MorganAntonio E. FriasDaniel N. StreblowNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Alec J. Hirsch Victoria H. J. Roberts Peta L. Grigsby Nicole Haese Matthias C. Schabel Xiaojie Wang Jamie O. Lo Zheng Liu Christopher D. Kroenke Jessica L. Smith Meredith Kelleher Rebecca Broeckel Craig N. Kreklywich Christopher J. Parkins Michael Denton Patricia Smith Victor DeFilippis William Messer Jay A. Nelson Jon D. Hennebold Marjorie Grafe Lois Colgin Anne Lewis Rebecca Ducore Tonya Swanson Alfred W. Legasse Michael K. Axthelm Rhonda MacAllister Ashlee V. Moses Terry K. Morgan Antonio E. Frias Daniel N. Streblow Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| description |
Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the placenta. |
| format |
article |
| author |
Alec J. Hirsch Victoria H. J. Roberts Peta L. Grigsby Nicole Haese Matthias C. Schabel Xiaojie Wang Jamie O. Lo Zheng Liu Christopher D. Kroenke Jessica L. Smith Meredith Kelleher Rebecca Broeckel Craig N. Kreklywich Christopher J. Parkins Michael Denton Patricia Smith Victor DeFilippis William Messer Jay A. Nelson Jon D. Hennebold Marjorie Grafe Lois Colgin Anne Lewis Rebecca Ducore Tonya Swanson Alfred W. Legasse Michael K. Axthelm Rhonda MacAllister Ashlee V. Moses Terry K. Morgan Antonio E. Frias Daniel N. Streblow |
| author_facet |
Alec J. Hirsch Victoria H. J. Roberts Peta L. Grigsby Nicole Haese Matthias C. Schabel Xiaojie Wang Jamie O. Lo Zheng Liu Christopher D. Kroenke Jessica L. Smith Meredith Kelleher Rebecca Broeckel Craig N. Kreklywich Christopher J. Parkins Michael Denton Patricia Smith Victor DeFilippis William Messer Jay A. Nelson Jon D. Hennebold Marjorie Grafe Lois Colgin Anne Lewis Rebecca Ducore Tonya Swanson Alfred W. Legasse Michael K. Axthelm Rhonda MacAllister Ashlee V. Moses Terry K. Morgan Antonio E. Frias Daniel N. Streblow |
| author_sort |
Alec J. Hirsch |
| title |
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_short |
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_full |
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_fullStr |
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_full_unstemmed |
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_sort |
zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/b27991f416df40acb0fbda1482c193c4 |
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