Age-related decrease of meiotic cohesins in human oocytes.

Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital birth defects. It is known that the frequency of oocyte aneuploidy increases with the human maternal age. Recent data have highlighted the contribution of cohesin complexes in the correct segregation of meiotic...

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Autores principales: Makiko Tsutsumi, Reiko Fujiwara, Haruki Nishizawa, Mayuko Ito, Hiroshi Kogo, Hidehito Inagaki, Tamae Ohye, Takema Kato, Takuma Fujii, Hiroki Kurahashi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/b2799bffe06948aeba34f44cd3730a72
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