Non-equilibrium hyperbolic transport in transcriptional regulation.

In this work we studied memory and irreversible transport phenomena in a non-equilibrium thermodynamical model for genomic transcriptional regulation. Transcriptional regulation possess an extremely complex phenomenology, and it is, of course, of foremost importance in organismal cell development an...

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Autores principales:	Enrique Hernández-Lemus, María D Correa-Rodríguez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b27b74f10c654f73ad95da47d13e71e1
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spelling	oai:doaj.org-article:b27b74f10c654f73ad95da47d13e71e12021-11-18T06:50:42ZNon-equilibrium hyperbolic transport in transcriptional regulation.1932-620310.1371/journal.pone.0021558https://doaj.org/article/b27b74f10c654f73ad95da47d13e71e12011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21754990/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203In this work we studied memory and irreversible transport phenomena in a non-equilibrium thermodynamical model for genomic transcriptional regulation. Transcriptional regulation possess an extremely complex phenomenology, and it is, of course, of foremost importance in organismal cell development and in the pathogenesis of complex diseases. A better understanding of the way in which these processes occur is mandatory to optimize the construction of gene regulatory networks, but also to connect these networks with multi-scale phenomena (e.g. metabolism, signalling pathways, etc.) under an integrative Systems Biology-like vision. In this paper we analyzed three simple mechanisms of genetic stimulation: an instant pulse, a periodic biochemical signal and a saturation process with sigmoidal kinetics and from these we derived the system's thermodynamical response, in the form of, for example, anomalous transcriptional bursts.Enrique Hernández-LemusMaría D Correa-RodríguezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21558 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enrique Hernández-Lemus María D Correa-Rodríguez Non-equilibrium hyperbolic transport in transcriptional regulation.
description	In this work we studied memory and irreversible transport phenomena in a non-equilibrium thermodynamical model for genomic transcriptional regulation. Transcriptional regulation possess an extremely complex phenomenology, and it is, of course, of foremost importance in organismal cell development and in the pathogenesis of complex diseases. A better understanding of the way in which these processes occur is mandatory to optimize the construction of gene regulatory networks, but also to connect these networks with multi-scale phenomena (e.g. metabolism, signalling pathways, etc.) under an integrative Systems Biology-like vision. In this paper we analyzed three simple mechanisms of genetic stimulation: an instant pulse, a periodic biochemical signal and a saturation process with sigmoidal kinetics and from these we derived the system's thermodynamical response, in the form of, for example, anomalous transcriptional bursts.
format	article
author	Enrique Hernández-Lemus María D Correa-Rodríguez
author_facet	Enrique Hernández-Lemus María D Correa-Rodríguez
author_sort	Enrique Hernández-Lemus
title	Non-equilibrium hyperbolic transport in transcriptional regulation.
title_short	Non-equilibrium hyperbolic transport in transcriptional regulation.
title_full	Non-equilibrium hyperbolic transport in transcriptional regulation.
title_fullStr	Non-equilibrium hyperbolic transport in transcriptional regulation.
title_full_unstemmed	Non-equilibrium hyperbolic transport in transcriptional regulation.
title_sort	non-equilibrium hyperbolic transport in transcriptional regulation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/b27b74f10c654f73ad95da47d13e71e1
work_keys_str_mv	AT enriquehernandezlemus nonequilibriumhyperbolictransportintranscriptionalregulation AT mariadcorrearodriguez nonequilibriumhyperbolictransportintranscriptionalregulation
_version_	1718424314678607872

Non-equilibrium hyperbolic transport in transcriptional regulation.

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