Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions

Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions

Rising rates of peanut allergy pose a public health problem. Here, the authors profile blood transcriptomes during double-blind, placebo-controlled oral challenge in peanut-allergic children to identify gene and cell composition changes, and construct causal networks to detect key allergic reaction ...

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Bibliographic Details
Main Authors: C. T. Watson, A. T. Cohain, R. S. Griffin, Y. Chun, A. Grishin, H. Hacyznska, G. E. Hoffman, N. D. Beckmann, H. Shah, P. Dawson, A. Henning, R. Wood, A. W. Burks, S. M. Jones, D. Y. M. Leung, S. Sicherer, H. A. Sampson, A. J. Sharp, E. E. Schadt, S. Bunyavanich
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/b27d5451d40c4093a9beecfb4a22c936
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Summary:Rising rates of peanut allergy pose a public health problem. Here, the authors profile blood transcriptomes during double-blind, placebo-controlled oral challenge in peanut-allergic children to identify gene and cell composition changes, and construct causal networks to detect key allergic reaction drivers.

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