Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions

Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions

Rising rates of peanut allergy pose a public health problem. Here, the authors profile blood transcriptomes during double-blind, placebo-controlled oral challenge in peanut-allergic children to identify gene and cell composition changes, and construct causal networks to detect key allergic reaction ...

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Autores principales: C. T. Watson, A. T. Cohain, R. S. Griffin, Y. Chun, A. Grishin, H. Hacyznska, G. E. Hoffman, N. D. Beckmann, H. Shah, P. Dawson, A. Henning, R. Wood, A. W. Burks, S. M. Jones, D. Y. M. Leung, S. Sicherer, H. A. Sampson, A. J. Sharp, E. E. Schadt, S. Bunyavanich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/b27d5451d40c4093a9beecfb4a22c936
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spelling oai:doaj.org-article:b27d5451d40c4093a9beecfb4a22c9362021-12-02T17:05:59ZIntegrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions10.1038/s41467-017-02188-72041-1723https://doaj.org/article/b27d5451d40c4093a9beecfb4a22c9362017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02188-7https://doaj.org/toc/2041-1723Rising rates of peanut allergy pose a public health problem. Here, the authors profile blood transcriptomes during double-blind, placebo-controlled oral challenge in peanut-allergic children to identify gene and cell composition changes, and construct causal networks to detect key allergic reaction drivers.C. T. WatsonA. T. CohainR. S. GriffinY. ChunA. GrishinH. HacyznskaG. E. HoffmanN. D. BeckmannH. ShahP. DawsonA. HenningR. WoodA. W. BurksS. M. JonesD. Y. M. LeungS. SichererH. A. SampsonA. J. SharpE. E. SchadtS. BunyavanichNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
C. T. Watson
A. T. Cohain
R. S. Griffin
Y. Chun
A. Grishin
H. Hacyznska
G. E. Hoffman
N. D. Beckmann
H. Shah
P. Dawson
A. Henning
R. Wood
A. W. Burks
S. M. Jones
D. Y. M. Leung
S. Sicherer
H. A. Sampson
A. J. Sharp
E. E. Schadt
S. Bunyavanich
Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
description Rising rates of peanut allergy pose a public health problem. Here, the authors profile blood transcriptomes during double-blind, placebo-controlled oral challenge in peanut-allergic children to identify gene and cell composition changes, and construct causal networks to detect key allergic reaction drivers.
format article
author C. T. Watson
A. T. Cohain
R. S. Griffin
Y. Chun
A. Grishin
H. Hacyznska
G. E. Hoffman
N. D. Beckmann
H. Shah
P. Dawson
A. Henning
R. Wood
A. W. Burks
S. M. Jones
D. Y. M. Leung
S. Sicherer
H. A. Sampson
A. J. Sharp
E. E. Schadt
S. Bunyavanich
author_facet C. T. Watson
A. T. Cohain
R. S. Griffin
Y. Chun
A. Grishin
H. Hacyznska
G. E. Hoffman
N. D. Beckmann
H. Shah
P. Dawson
A. Henning
R. Wood
A. W. Burks
S. M. Jones
D. Y. M. Leung
S. Sicherer
H. A. Sampson
A. J. Sharp
E. E. Schadt
S. Bunyavanich
author_sort C. T. Watson
title Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
title_short Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
title_full Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
title_fullStr Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
title_full_unstemmed Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
title_sort integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b27d5451d40c4093a9beecfb4a22c936
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