Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis

Tubular cell senescence is a common biologic process and contributes to the progression of chronic kidney disease (CKD); however, the molecular mechanisms regulating tubular cell senescence are poorly understood. Here, we report that integrin β3 (ITGB3) expression was increased in tubular cells and...

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Autores principales:	Shen Li, Song Jiang, Qingyan Zhang, Bo Jin, Daoyuan Lv, Wenju Li, Min Zhao, Chunming Jiang, Chunsun Dai, Zhihong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ITGB3 isoliquiritigenin renal fibrosis cell senescence TGF-β1 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b282fd4f7911472c843b55a64193d742
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spelling	oai:doaj.org-article:b282fd4f7911472c843b55a64193d7422021-11-05T06:33:43ZIntegrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis2296-634X10.3389/fcell.2021.733831https://doaj.org/article/b282fd4f7911472c843b55a64193d7422021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.733831/fullhttps://doaj.org/toc/2296-634XTubular cell senescence is a common biologic process and contributes to the progression of chronic kidney disease (CKD); however, the molecular mechanisms regulating tubular cell senescence are poorly understood. Here, we report that integrin β3 (ITGB3) expression was increased in tubular cells and positively correlated with fibrosis degree in CKD patients. ITGB3 overexpression could induce p53 pathway activation and the secretion of TGF-β, which, in turn, resulted in senescent and profibrotic phenotype change in cultured tubular cells. Moreover, according to the CMAP database, we identified isoliquiritigenin (ISL) as an agent to inhibit ITGB3. ISL treatment could suppress Itgb3 expression, attenuate cellular senescence, and prevent renal fibrosis in mice. These results reveal a crucial role for integrin signaling in cellular senescence, potentially identifying a new therapeutic direction for kidney fibrosis.Shen LiShen LiSong JiangQingyan ZhangBo JinDaoyuan LvWenju LiMin ZhaoChunming JiangChunsun DaiChunsun DaiZhihong LiuFrontiers Media S.A.articleITGB3isoliquiritigeninrenal fibrosiscell senescenceTGF-β1Biology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ITGB3 isoliquiritigenin renal fibrosis cell senescence TGF-β1 Biology (General) QH301-705.5
spellingShingle	ITGB3 isoliquiritigenin renal fibrosis cell senescence TGF-β1 Biology (General) QH301-705.5 Shen Li Shen Li Song Jiang Qingyan Zhang Bo Jin Daoyuan Lv Wenju Li Min Zhao Chunming Jiang Chunsun Dai Chunsun Dai Zhihong Liu Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
description	Tubular cell senescence is a common biologic process and contributes to the progression of chronic kidney disease (CKD); however, the molecular mechanisms regulating tubular cell senescence are poorly understood. Here, we report that integrin β3 (ITGB3) expression was increased in tubular cells and positively correlated with fibrosis degree in CKD patients. ITGB3 overexpression could induce p53 pathway activation and the secretion of TGF-β, which, in turn, resulted in senescent and profibrotic phenotype change in cultured tubular cells. Moreover, according to the CMAP database, we identified isoliquiritigenin (ISL) as an agent to inhibit ITGB3. ISL treatment could suppress Itgb3 expression, attenuate cellular senescence, and prevent renal fibrosis in mice. These results reveal a crucial role for integrin signaling in cellular senescence, potentially identifying a new therapeutic direction for kidney fibrosis.
format	article
author	Shen Li Shen Li Song Jiang Qingyan Zhang Bo Jin Daoyuan Lv Wenju Li Min Zhao Chunming Jiang Chunsun Dai Chunsun Dai Zhihong Liu
author_facet	Shen Li Shen Li Song Jiang Qingyan Zhang Bo Jin Daoyuan Lv Wenju Li Min Zhao Chunming Jiang Chunsun Dai Chunsun Dai Zhihong Liu
author_sort	Shen Li
title	Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
title_short	Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
title_full	Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
title_fullStr	Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
title_full_unstemmed	Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
title_sort	integrin β3 induction promotes tubular cell senescence and kidney fibrosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b282fd4f7911472c843b55a64193d742
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Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis

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