AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis

Abstract Fibrosis is a hallmark of heart disease independent of etiology and is thought to contribute to impaired cardiac dysfunction and development of heart failure. However, the underlying mechanisms that regulate the differentiation of fibroblasts to myofibroblasts and fibrotic responses remain...

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Main Authors: Jamie Francisco, Yu Zhang, Yasuki Nakada, Jae Im Jeong, Chun-Yang Huang, Andreas Ivessa, Shinichi Oka, Gopal J. Babu, Dominic P. Del Re
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/b2840988f77d4ca4a9dc4722061f9f74
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