Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling

Long noncoding RNAs have been shown to play a role in cardiovascular disease. Here, the authors identify a lncRNA named CCRR, whose downregulation in failing hearts causes cardiac conduction disturbances by altering the endocytic trafficking of Cx43.

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Autores principales: Yong Zhang, Lihua Sun, Lina Xuan, Zhenwei Pan, Xueling Hu, Hongyu Liu, Yunlong Bai, Lei Jiao, Zhange Li, Lina Cui, Xiaoxue Wang, Siqi Wang, Tingting Yu, Bingbing Feng, Ying Guo, Zonghong Liu, Weixin Meng, Hequn Ren, Jiyuan Zhu, Xuyun Zhao, Chao Yang, Ying Zhang, Chaoqian Xu, Zhiguo Wang, Yanjie Lu, Hongli Shan, Baofeng Yang
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b2856093b13b442281c99532c0c06980
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spelling oai:doaj.org-article:b2856093b13b442281c99532c0c069802021-12-02T17:31:29ZLong non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling10.1038/s41467-018-06637-92041-1723https://doaj.org/article/b2856093b13b442281c99532c0c069802018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06637-9https://doaj.org/toc/2041-1723Long noncoding RNAs have been shown to play a role in cardiovascular disease. Here, the authors identify a lncRNA named CCRR, whose downregulation in failing hearts causes cardiac conduction disturbances by altering the endocytic trafficking of Cx43.Yong ZhangLihua SunLina XuanZhenwei PanXueling HuHongyu LiuYunlong BaiLei JiaoZhange LiLina CuiXiaoxue WangSiqi WangTingting YuBingbing FengYing GuoZonghong LiuWeixin MengHequn RenJiyuan ZhuXuyun ZhaoChao YangYing ZhangChaoqian XuZhiguo WangYanjie LuHongli ShanBaofeng YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yong Zhang
Lihua Sun
Lina Xuan
Zhenwei Pan
Xueling Hu
Hongyu Liu
Yunlong Bai
Lei Jiao
Zhange Li
Lina Cui
Xiaoxue Wang
Siqi Wang
Tingting Yu
Bingbing Feng
Ying Guo
Zonghong Liu
Weixin Meng
Hequn Ren
Jiyuan Zhu
Xuyun Zhao
Chao Yang
Ying Zhang
Chaoqian Xu
Zhiguo Wang
Yanjie Lu
Hongli Shan
Baofeng Yang
Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
description Long noncoding RNAs have been shown to play a role in cardiovascular disease. Here, the authors identify a lncRNA named CCRR, whose downregulation in failing hearts causes cardiac conduction disturbances by altering the endocytic trafficking of Cx43.
format article
author Yong Zhang
Lihua Sun
Lina Xuan
Zhenwei Pan
Xueling Hu
Hongyu Liu
Yunlong Bai
Lei Jiao
Zhange Li
Lina Cui
Xiaoxue Wang
Siqi Wang
Tingting Yu
Bingbing Feng
Ying Guo
Zonghong Liu
Weixin Meng
Hequn Ren
Jiyuan Zhu
Xuyun Zhao
Chao Yang
Ying Zhang
Chaoqian Xu
Zhiguo Wang
Yanjie Lu
Hongli Shan
Baofeng Yang
author_facet Yong Zhang
Lihua Sun
Lina Xuan
Zhenwei Pan
Xueling Hu
Hongyu Liu
Yunlong Bai
Lei Jiao
Zhange Li
Lina Cui
Xiaoxue Wang
Siqi Wang
Tingting Yu
Bingbing Feng
Ying Guo
Zonghong Liu
Weixin Meng
Hequn Ren
Jiyuan Zhu
Xuyun Zhao
Chao Yang
Ying Zhang
Chaoqian Xu
Zhiguo Wang
Yanjie Lu
Hongli Shan
Baofeng Yang
author_sort Yong Zhang
title Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
title_short Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
title_full Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
title_fullStr Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
title_full_unstemmed Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
title_sort long non-coding rna ccrr controls cardiac conduction via regulating intercellular coupling
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/b2856093b13b442281c99532c0c06980
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